ID   ACTT2_HUMAN             Reviewed;         377 AA.
AC   Q8TDY3; B1AN52; Q8NHS6; Q8TDG1;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 2.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Actin-related protein T2;
DE            Short=ARP-T2;
DE   AltName: Full=Actin-related protein M2;
GN   Name=ACTRT2; Synonyms=ARPM2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11750065; DOI=10.1016/s0167-4781(01)00315-3;
RA   Harata M., Nishimori K., Hatta S.;
RT   "Identification of two cDNAs for human actin-related proteins (Arps) that
RT   have remarkable similarity to conventional actin.";
RL   Biochim. Biophys. Acta 1522:130-133(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12243744; DOI=10.1006/excr.2002.5603;
RA   Heid H.W., Figge U., Winter S., Kuhn C., Zimbelmann R., Franke W.W.;
RT   "Novel actin-related proteins Arp-T1 and Arp-T2 as components of the
RT   cytoskeletal calyx of the mammalian sperm head.";
RL   Exp. Cell Res. 279:177-187(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; AB057364; BAB85862.1; -; mRNA.
DR   EMBL; AF440740; AAM00433.1; -; mRNA.
DR   EMBL; AL356984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471248; EAW61142.1; -; Genomic_DNA.
DR   EMBL; BC029499; AAH29499.1; -; mRNA.
DR   CCDS; CCDS45.1; -.
DR   RefSeq; NP_536356.3; NM_080431.4.
DR   AlphaFoldDB; Q8TDY3; -.
DR   SMR; Q8TDY3; -.
DR   BioGRID; 126639; 12.
DR   STRING; 9606.ENSP00000367658; -.
DR   iPTMnet; Q8TDY3; -.
DR   PhosphoSitePlus; Q8TDY3; -.
DR   BioMuta; ACTRT2; -.
DR   DMDM; 47115879; -.
DR   MassIVE; Q8TDY3; -.
DR   PaxDb; Q8TDY3; -.
DR   PeptideAtlas; Q8TDY3; -.
DR   PRIDE; Q8TDY3; -.
DR   ProteomicsDB; 74370; -.
DR   Antibodypedia; 1628; 132 antibodies from 25 providers.
DR   DNASU; 140625; -.
DR   Ensembl; ENST00000378404.4; ENSP00000367658.2; ENSG00000169717.7.
DR   GeneID; 140625; -.
DR   KEGG; hsa:140625; -.
DR   MANE-Select; ENST00000378404.4; ENSP00000367658.2; NM_080431.5; NP_536356.3.
DR   UCSC; uc001ajz.4; human.
DR   CTD; 140625; -.
DR   DisGeNET; 140625; -.
DR   GeneCards; ACTRT2; -.
DR   HGNC; HGNC:24026; ACTRT2.
DR   HPA; ENSG00000169717; Tissue enriched (testis).
DR   MIM; 608535; gene.
DR   neXtProt; NX_Q8TDY3; -.
DR   OpenTargets; ENSG00000169717; -.
DR   PharmGKB; PA142672647; -.
DR   VEuPathDB; HostDB:ENSG00000169717; -.
DR   eggNOG; KOG0676; Eukaryota.
DR   GeneTree; ENSGT00940000162911; -.
DR   HOGENOM; CLU_027965_0_2_1; -.
DR   InParanoid; Q8TDY3; -.
DR   OMA; SITKCDA; -.
DR   OrthoDB; 708610at2759; -.
DR   PhylomeDB; Q8TDY3; -.
DR   TreeFam; TF354237; -.
DR   PathwayCommons; Q8TDY3; -.
DR   SignaLink; Q8TDY3; -.
DR   BioGRID-ORCS; 140625; 8 hits in 1063 CRISPR screens.
DR   GenomeRNAi; 140625; -.
DR   Pharos; Q8TDY3; Tdark.
DR   PRO; PR:Q8TDY3; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8TDY3; protein.
DR   Bgee; ENSG00000169717; Expressed in left testis and 44 other tissues.
DR   Genevisible; Q8TDY3; HS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR027666; ACTRT2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF38; PTHR11937:SF38; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..377
FT                   /note="Actin-related protein T2"
FT                   /id="PRO_0000089144"
FT   VARIANT         247
FT                   /note="G -> R (in dbSNP:rs3795263)"
FT                   /id="VAR_020416"
FT   CONFLICT        55
FT                   /note="Missing (in Ref. 5; AAH29499)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        224
FT                   /note="A -> P (in Ref. 1; BAB85862)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   377 AA;  41702 MW;  73272DE854B48FEB CRC64;
     MFNPHALDSP AVIFDNGSGF CKAGLSGEFG PRHMVSSIVG HLKFQAPSAE ANQKKYFVGE
     EALYKQEALQ LHSPFERGLI TGWDDVERLW KHLFEWELGV KPSDQPLLAT EPSLNPRENR
     EKMAEVMFEN FGVPAFYLSD QAVLALYASA CVTGLVVDSG DAVTCTVPIF EGYSLPHAVT
     KLHVAGRDIT ELLMQLLLAS GHTFPCQLDK GLVDDIKKKL CYVALEPEKE LSRRPEEVLR
     EYKLPDGNII SLGDPLHQAP EALFVPQQLG SQSPGLSNMV SSSITKCDTD IQKILFGEIV
     LSGGTTLFHG LDDRLLKELE QLASKDTPIK ITAPPDRWFS TWIGASIVTS LSSFKQMWVT
     AADFKEFGTS VVQRRCF