ACTT2_MOUSE
ID ACTT2_MOUSE Reviewed; 377 AA.
AC Q9D9L5;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Actin-related protein T2;
DE Short=ARP-T2;
DE AltName: Full=Actin-related protein M2;
GN Name=Actrt2; Synonyms=Arpm2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR EMBL; AK006772; BAB24733.1; -; mRNA.
DR EMBL; BC052344; AAH52344.1; -; mRNA.
DR CCDS; CCDS19014.1; -.
DR RefSeq; NP_082789.1; NM_028513.3.
DR AlphaFoldDB; Q9D9L5; -.
DR SMR; Q9D9L5; -.
DR STRING; 10090.ENSMUSP00000050377; -.
DR iPTMnet; Q9D9L5; -.
DR PhosphoSitePlus; Q9D9L5; -.
DR PaxDb; Q9D9L5; -.
DR PRIDE; Q9D9L5; -.
DR ProteomicsDB; 285857; -.
DR Antibodypedia; 1628; 132 antibodies from 25 providers.
DR DNASU; 73353; -.
DR Ensembl; ENSMUST00000060062; ENSMUSP00000050377; ENSMUSG00000051276.
DR GeneID; 73353; -.
DR KEGG; mmu:73353; -.
DR UCSC; uc008wca.2; mouse.
DR CTD; 140625; -.
DR MGI; MGI:1920603; Actrt2.
DR VEuPathDB; HostDB:ENSMUSG00000051276; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000162911; -.
DR HOGENOM; CLU_027965_0_2_1; -.
DR InParanoid; Q9D9L5; -.
DR OMA; SITKCDA; -.
DR OrthoDB; 708610at2759; -.
DR PhylomeDB; Q9D9L5; -.
DR TreeFam; TF354237; -.
DR BioGRID-ORCS; 73353; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Actrt2; mouse.
DR PRO; PR:Q9D9L5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9D9L5; protein.
DR Bgee; ENSMUSG00000051276; Expressed in spermatid and 28 other tissues.
DR Genevisible; Q9D9L5; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR027666; ACTRT2.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR PANTHER; PTHR11937:SF38; PTHR11937:SF38; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..377
FT /note="Actin-related protein T2"
FT /id="PRO_0000089145"
SQ SEQUENCE 377 AA; 41616 MW; BCDE0F34BC5C88B6 CRC64;
MFNPLVLDSP SVIFDNGSGL CKAGLSGEIG PRHVTSSVVG YPKFKAPPTG ASQKKYFVGE
EALYKQEALS LHYPIDRGLV TSWDDVEKLW RHLFEWELGV KPCERPVLVT EPSLNPRENR
EKTAEMMFET FEVPAFYLSD QAVLALYSSA CVTGLVVDSG DGVTCTVPIY EGYSLPHAVS
KLYVAGKDIT ELLTRLLLAS GRAFPCPLEK ALADDIKEKL CYVALEPEEE LSRRAEDVLR
EYKLPDGNVI YIGDQLYQAP EVLFSPDQLG THGPGLAQMA SNSITKCDAD IQKTLFGEIV
LSGGSTLFQG LDDRLLKELE QLASKGVPIK ITAPPDRWFS TWIGASIVTS LSSFKQMWIT
AADFKEFGVS VVQRRCF
