ACTT3_HUMAN
ID ACTT3_HUMAN Reviewed; 372 AA.
AC Q9BYD9; Q96IS0; Q96NJ0;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Actin-related protein T3;
DE Short=ARP-T3;
DE AltName: Full=Actin-related protein M1;
GN Name=ACTRT3; Synonyms=ARPM1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=11750065; DOI=10.1016/s0167-4781(01)00315-3;
RA Harata M., Nishimori K., Hatta S.;
RT "Identification of two cDNAs for human actin-related proteins (Arps) that
RT have remarkable similarity to conventional actin.";
RL Biochim. Biophys. Acta 1522:130-133(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with PFN3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm
CC {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:11750065}.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR EMBL; AB049117; BAB39481.1; -; mRNA.
DR EMBL; AK055346; BAB70906.1; -; mRNA.
DR EMBL; AC078802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC007289; AAH07289.1; -; mRNA.
DR CCDS; CCDS3206.1; -.
DR RefSeq; NP_115876.3; NM_032487.4.
DR AlphaFoldDB; Q9BYD9; -.
DR SMR; Q9BYD9; -.
DR BioGRID; 124111; 1.
DR STRING; 9606.ENSP00000333037; -.
DR BioMuta; ACTRT3; -.
DR DMDM; 47116738; -.
DR MassIVE; Q9BYD9; -.
DR PaxDb; Q9BYD9; -.
DR PeptideAtlas; Q9BYD9; -.
DR PRIDE; Q9BYD9; -.
DR ProteomicsDB; 79622; -.
DR Antibodypedia; 33699; 138 antibodies from 23 providers.
DR DNASU; 84517; -.
DR Ensembl; ENST00000330368.3; ENSP00000333037.1; ENSG00000184378.3.
DR GeneID; 84517; -.
DR KEGG; hsa:84517; -.
DR MANE-Select; ENST00000330368.3; ENSP00000333037.1; NM_032487.5; NP_115876.3.
DR UCSC; uc003ffs.3; human.
DR CTD; 84517; -.
DR DisGeNET; 84517; -.
DR GeneCards; ACTRT3; -.
DR HGNC; HGNC:24022; ACTRT3.
DR HPA; ENSG00000184378; Tissue enriched (testis).
DR MIM; 608534; gene.
DR neXtProt; NX_Q9BYD9; -.
DR OpenTargets; ENSG00000184378; -.
DR VEuPathDB; HostDB:ENSG00000184378; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000162209; -.
DR HOGENOM; CLU_027965_0_2_1; -.
DR InParanoid; Q9BYD9; -.
DR OMA; WEDMEIM; -.
DR OrthoDB; 649708at2759; -.
DR PhylomeDB; Q9BYD9; -.
DR TreeFam; TF337161; -.
DR PathwayCommons; Q9BYD9; -.
DR SignaLink; Q9BYD9; -.
DR BioGRID-ORCS; 84517; 28 hits in 1078 CRISPR screens.
DR GenomeRNAi; 84517; -.
DR Pharos; Q9BYD9; Tdark.
DR PRO; PR:Q9BYD9; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9BYD9; protein.
DR Bgee; ENSG00000184378; Expressed in sperm and 106 other tissues.
DR Genevisible; Q9BYD9; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR030068; ARP-T3.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR PANTHER; PTHR11937:SF159; PTHR11937:SF159; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT CHAIN 1..372
FT /note="Actin-related protein T3"
FT /id="PRO_0000089142"
FT VARIANT 234
FT /note="E -> K (in dbSNP:rs2068178)"
FT /id="VAR_055483"
FT CONFLICT 78
FT /note="W -> C (in Ref. 3; AAH07289)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="C -> R (in Ref. 2; BAB70906)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 372 AA; 41008 MW; 56413BCF02AA4794 CRC64;
MNHCQLPVVI DNGSGMIKAG VAGCREPQFI YPNIIGRAKG QSRAAQGGLE LCVGDQAQDW
RSSLFISYPV ERGLITSWED MEIMWKHIYD YNLKLKPCDG PVLITEPALN PLANRQQITE
MFFEHLGVPA FYMSIQAVLA LFAAGFTTGL VLNSGAGVTQ SVPIFEGYCL PHGVQQLDLA
GLDLTNYLMV LMKNHGIMLL SASDRKIVED IKESFCYVAM NYEEEMAKKP DCLEKVYQLP
DGKVIQLHDQ LFSCPEALFS PCHMNLEAPG IDKICFSSIM KCDTGLRNSF FSNIILAGGS
TSFPGLDKRL VKDIAKVAPA NTAVQVIAPP ERKISVWMGG SILASLSAFQ DMWITAAEFK
EVGPNIVHQR CF
