ACTT3_MOUSE
ID ACTT3_MOUSE Reviewed; 369 AA.
AC Q8BXF8; Q3KNH6; Q9D9A6;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Actin-related protein T3;
DE Short=ARP-T3;
DE AltName: Full=Actin-related protein M1;
GN Name=Actrt3; Synonyms=Arpm1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH PFN3.
RX PubMed=18692047; DOI=10.1016/j.febslet.2008.07.058;
RA Hara Y., Yamagata K., Oguchi K., Baba T.;
RT "Nuclear localization of profilin III-ArpM1 complex in mouse
RT spermiogenesis.";
RL FEBS Lett. 582:2998-3004(2008).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with PFN3. {ECO:0000269|PubMed:18692047}.
CC -!- INTERACTION:
CC Q8BXF8; Q9DAD6: Pfn3; NbExp=3; IntAct=EBI-6480313, EBI-6480328;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm
CC {ECO:0000269|PubMed:18692047}. Nucleus {ECO:0000269|PubMed:18692047}.
CC Note=The localization changes from the peripheral region to inside the
CC nucleus during differentiation from round to elongated spermatid.
CC -!- TISSUE SPECIFICITY: Testis specific (at protein level). Expressed
CC specifically in haploid germ cells.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24897.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK007208; BAB24897.1; ALT_INIT; mRNA.
DR EMBL; AK047260; BAC33006.1; -; mRNA.
DR EMBL; BC107277; AAI07278.1; -; mRNA.
DR EMBL; BC107278; AAI07279.1; -; mRNA.
DR CCDS; CCDS17283.1; -.
DR RefSeq; NP_083966.1; NM_029690.2.
DR AlphaFoldDB; Q8BXF8; -.
DR SMR; Q8BXF8; -.
DR IntAct; Q8BXF8; 5.
DR MINT; Q8BXF8; -.
DR STRING; 10090.ENSMUSP00000048360; -.
DR REPRODUCTION-2DPAGE; IPI00226663; -.
DR PaxDb; Q8BXF8; -.
DR PRIDE; Q8BXF8; -.
DR ProteomicsDB; 285721; -.
DR Antibodypedia; 33699; 138 antibodies from 23 providers.
DR DNASU; 76652; -.
DR Ensembl; ENSMUST00000047630; ENSMUSP00000048360; ENSMUSG00000037737.
DR GeneID; 76652; -.
DR KEGG; mmu:76652; -.
DR UCSC; uc008ouw.1; mouse.
DR CTD; 84517; -.
DR MGI; MGI:1923902; Actrt3.
DR VEuPathDB; HostDB:ENSMUSG00000037737; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000162209; -.
DR HOGENOM; CLU_027965_0_2_1; -.
DR InParanoid; Q8BXF8; -.
DR OMA; WEDMEIM; -.
DR OrthoDB; 649708at2759; -.
DR PhylomeDB; Q8BXF8; -.
DR TreeFam; TF337161; -.
DR BioGRID-ORCS; 76652; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8BXF8; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8BXF8; protein.
DR Bgee; ENSMUSG00000037737; Expressed in seminiferous tubule of testis and 17 other tissues.
DR Genevisible; Q8BXF8; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0001673; C:male germ cell nucleus; IDA:UniProtKB.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR030068; ARP-T3.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR PANTHER; PTHR11937:SF159; PTHR11937:SF159; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT CHAIN 1..369
FT /note="Actin-related protein T3"
FT /id="PRO_0000089143"
FT CONFLICT 1
FT /note="M -> L (in Ref. 1; BAB24897)"
FT /evidence="ECO:0000305"
FT CONFLICT 236
FT /note="L -> Q (in Ref. 1; BAB24897)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 369 AA; 40443 MW; B08DD010D5504BBD CRC64;
MSGYQPPVVI DNGSGMIKAG LAGTREPQFV YPNILGRSKG HTADSRQELC VGDQAQERRS
FLSISYPVER GLISSWGDME IMWKHIYDYN LNLNASDGPV LVTEPALNPL ADRQHISEVF
FENLGVPAFY MSAQAVLALF AAGFTTGLVL NSGAGITQCV PIFEGYCLSH GVKQLNVAGS
DLTSYLMMLL KGDGIMLLRT GDRKVVTDIK ENACYVAMNY EDEMTKDSNL EKIYTLPDGK
TVKLHKQLFH CPEALFSPYL VNVDAPGIDK MCFGSIMKCD TDLRNSFFSN IILSGGSTSF
PGLDKRLIKD VAKLAPANTA VQVIAPPERK ISVWMGGSIL ASLSAFQDMW ITAAEFEEVG
PNIVHQRCF
