DCHM_BPT6
ID DCHM_BPT6 Reviewed; 246 AA.
AC P18030;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 23-FEB-2022, entry version 83.
DE RecName: Full=Deoxycytidylate 5-hydroxymethyltransferase;
DE Short=Deoxycytidylate hydroxymethylase;
DE EC=2.1.2.8;
DE AltName: Full=dCMP hydroxymethylase;
DE Short=dCMP HMase;
GN Name=42;
OS Enterobacteria phage T6 (Bacteriophage T6).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus;
OC Enterobacteria virus T6.
OX NCBI_TaxID=10666;
OH NCBI_TaxID=562; Escherichia coli.
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=3350013; DOI=10.1111/j.1432-1033.1988.tb13925.x;
RA Lamm N., Wang Y., Mathews C.K., Rueger W.;
RT "Deoxycytidylate hydroxymethylase gene of bacteriophage T4. Nucleotide
RT sequence determination and over-expression of the gene.";
RL Eur. J. Biochem. 172:553-563(1988).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O =
CC (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP;
CC Xref=Rhea:RHEA:11280, ChEBI:CHEBI:15377, ChEBI:CHEBI:15636,
CC ChEBI:CHEBI:57453, ChEBI:CHEBI:57566, ChEBI:CHEBI:57962; EC=2.1.2.8;
CC -!- SIMILARITY: Belongs to the thymidylate synthase family. {ECO:0000305}.
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DR PIR; B34273; SZBPT6.
DR SMR; P18030; -.
DR GO; GO:0047153; F:deoxycytidylate 5-hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.572.10; -; 1.
DR InterPro; IPR014619; Deoxycytidylate_hydroxyMease.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR PANTHER; PTHR11548; PTHR11548; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PIRSF; PIRSF036750; dCMP_HMase; 1.
DR SUPFAM; SSF55831; SSF55831; 1.
PE 3: Inferred from homology;
KW Transferase.
FT CHAIN 1..246
FT /note="Deoxycytidylate 5-hydroxymethyltransferase"
FT /id="PRO_0000141069"
FT ACT_SITE 148
FT /evidence="ECO:0000255"
SQ SEQUENCE 246 AA; 28621 MW; A370095E32451E8D CRC64;
MISDSMTVEE IRLHLGLALK EKDFVVDKTG VKTIEIIGAS FVADEPFIFG ALNDEYIQRE
LEWYKSKSLF VKDIPGETPK IWQQVASSKG EINSNYGWAI WSEDNYAQYD MCLAELGQNP
DSRRGIMIYT RPSMQFDYNK DGMSDFMCTN TVQYLIRDKK INAVVNMRSN DVVFGFRNDY
AWQKYVLDKL VSDLNAGDPT RQYKAGSIIW NVGSLHVYSR HFYLVDHWWK TGETHIVKKD
YKGEWK