ID   DCHS_LENBU              Reviewed;         115 AA.
AC   P04193;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Histidine decarboxylase proenzyme;
DE            Short=HDC;
DE            EC=4.1.1.22;
DE   AltName: Full=Pi chain;
DE   Contains:
DE     RecName: Full=Histidine decarboxylase beta chain;
DE   Contains:
DE     RecName: Full=Histidine decarboxylase alpha chain;
DE   Flags: Fragment;
OS   Lentilactobacillus buchneri (Lactobacillus buchneri).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lentilactobacillus.
OX   NCBI_TaxID=1581;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-115, AND PYRUVATE FORMATION AT SER-83.
RX   PubMed=2857718; DOI=10.1016/s0021-9258(18)89433-9;
RA   Huynh Q.K., Snell E.E.;
RT   "Pyruvoyl-dependent histidine decarboxylases. Preparation and amino acid
RT   sequences of the beta chains of histidine decarboxylase from Clostridium
RT   perfringens and Lactobacillus buchneri.";
RL   J. Biol. Chem. 260:2798-2803(1985).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-histidine = CO2 + histamine; Xref=Rhea:RHEA:20840,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57595,
CC         ChEBI:CHEBI:58432; EC=4.1.1.22;
CC   -!- COFACTOR:
CC       Name=pyruvate; Xref=ChEBI:CHEBI:15361;
CC       Note=Binds 1 pyruvoyl group covalently per subunit.;
CC   -!- SUBUNIT: The proenzyme is a hexamer of identical pi chains; each pi
CC       chain monomer is cleaved to form a small (or beta) chain and a large
CC       (or alpha) chain by non-hydrolytic self-catalysis.
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DR   PIR; A01080; DCLBHB.
DR   AlphaFoldDB; P04193; -.
DR   SMR; P04193; -.
DR   MEROPS; X39.001; -.
DR   SABIO-RK; P04193; -.
DR   GO; GO:0004398; F:histidine decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006547; P:histidine metabolic process; IEA:InterPro.
DR   Gene3D; 3.50.20.10; -; 1.
DR   Gene3D; 4.10.510.10; -; 1.
DR   InterPro; IPR003427; His_de-COase_proenz.
DR   InterPro; IPR016106; Pyr-dep_his-deCO2ase_N.
DR   InterPro; IPR016104; Pyr-dep_his/arg-deCO2ase.
DR   InterPro; IPR016105; Pyr-dep_his/arg-deCO2ase_sand.
DR   Pfam; PF02329; HDC; 1.
DR   SUPFAM; SSF56271; SSF56271; 1.
PE   1: Evidence at protein level;
KW   Decarboxylase; Direct protein sequencing; Lyase; Pyruvate; Zymogen.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:2857718"
FT   CHAIN           2..82
FT                   /note="Histidine decarboxylase beta chain"
FT                   /id="PRO_0000029955"
FT   CHAIN           83..>115
FT                   /note="Histidine decarboxylase alpha chain"
FT                   /id="PRO_0000029956"
FT   SITE            82..83
FT                   /note="Cleavage (non-hydrolytic)"
FT   MOD_RES         83
FT                   /note="Pyruvic acid (Ser)"
FT                   /evidence="ECO:0000269|PubMed:2857718"
FT   NON_TER         115
SQ   SEQUENCE   115 AA;  12621 MW;  88904E2C471BA7B5 CRC64;
     MSEFDKKLNT LGVDRISVSP YKKWSRGYME PGNIGNGYVS GLKVDAGVVD KTDDMVLDGI
     GSYDRAETKN AYIGQINMTT ASSFSGVGGT VISYDILRNP EVDKAKPLFT EKQWD