ID   DCHS_MICSP              Reviewed;          38 AA.
AC   P00863;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Histidine decarboxylase small chain;
DE            Short=HDC;
DE            EC=4.1.1.22;
DE   Flags: Fragment;
OS   Micrococcus sp.
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Micrococcus;
OC   unclassified Micrococcus.
OX   NCBI_TaxID=1271;
RN   [1]
RP   PROTEIN SEQUENCE.
RA   Prozorovski V., Joernvall H.;
RT   "Structural studies of histidine decarboxylase from Micrococcus sp. N.";
RL   Eur. J. Biochem. 53:169-174(1975).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-histidine = CO2 + histamine; Xref=Rhea:RHEA:20840,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57595,
CC         ChEBI:CHEBI:58432; EC=4.1.1.22;
CC   -!- COFACTOR:
CC       Name=pyruvate; Xref=ChEBI:CHEBI:15361;
CC       Note=Binds 1 pyruvoyl group covalently per subunit.;
CC   -!- SUBUNIT: Heterohexamer of 3 large and 3 small chains.
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DR   AlphaFoldDB; P00863; -.
DR   SMR; P00863; -.
DR   GO; GO:0004398; F:histidine decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 4.10.510.10; -; 1.
DR   InterPro; IPR016106; Pyr-dep_his-deCO2ase_N.
DR   InterPro; IPR016104; Pyr-dep_his/arg-deCO2ase.
DR   SUPFAM; SSF56271; SSF56271; 1.
PE   1: Evidence at protein level;
KW   Decarboxylase; Direct protein sequencing; Lyase; Pyruvate.
FT   CHAIN           1..>38
FT                   /note="Histidine decarboxylase small chain"
FT                   /id="PRO_0000157474"
FT   NON_TER         38
SQ   SEQUENCE   38 AA;  4349 MW;  2707FDCD8277D7DC CRC64;
     MKKTDKILKE IGIQRVAIME GKKYSKGFME DGDIGVQY