ID   DCH_THAAR               Reviewed;         258 AA.
AC   O87873;
DT   24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Cyclohexa-1,5-dienecarbonyl-CoA hydratase;
DE            EC=4.2.1.100;
DE   AltName: Full=Cyclohexa-1,5-diene-1-carboxyl-CoA hydratase;
DE            Short=Dienoyl-CoA hydratase;
GN   Name=dch;
OS   Thauera aromatica.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC   Thauera.
OX   NCBI_TaxID=59405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9746358; DOI=10.1046/j.1432-1327.1998.2560148.x;
RA   Breese K., Boll M., Alt-Moerbe J., Schaegger H., Fuchs G.;
RT   "Genes coding for the benzoyl-CoA pathway of anaerobic aromatic metabolism
RT   in the bacterium Thauera aromatica.";
RL   Eur. J. Biochem. 256:148-154(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-21, AND CHARACTERIZATION.
RX   PubMed=9738901; DOI=10.1046/j.1432-1327.1998.2550618.x;
RA   Laempe D., Eisenreich W., Bacher A., Fuchs G.;
RT   "Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase, an enzyme involved in
RT   anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera
RT   aromatica.";
RL   Eur. J. Biochem. 255:618-627(1998).
CC   -!- FUNCTION: Catalyzes the hydration of cyclohexa-1,5-diene-1-carboxyl-
CC       CoA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-
CC         1-ene-1-carbonyl-CoA; Xref=Rhea:RHEA:21856, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:57361, ChEBI:CHEBI:57374; EC=4.2.1.100;
CC   -!- PATHWAY: Aromatic compound metabolism; benzoyl-CoA degradation.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000305}.
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DR   EMBL; AJ224959; CAA12246.1; -; Genomic_DNA.
DR   AlphaFoldDB; O87873; -.
DR   SMR; O87873; -.
DR   KEGG; ag:CAA12246; -.
DR   UniPathway; UPA00739; -.
DR   GO; GO:0018823; F:cyclohexa-1,5-dienecarbonyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.12.10; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR017602; Dienoyl_CoA_hydratase.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   TIGRFAMs; TIGR03189; dienoyl_CoA_hyt; 1.
PE   1: Evidence at protein level;
KW   Aromatic hydrocarbons catabolism; Direct protein sequencing; Lyase.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:9738901"
FT   CHAIN           2..258
FT                   /note="Cyclohexa-1,5-dienecarbonyl-CoA hydratase"
FT                   /id="PRO_0000109323"
SQ   SEQUENCE   258 AA;  27882 MW;  50E70F51A851762C CRC64;
     MSEASSPLKV WLERDGSLLR LRLARPKANI VDAAMIAAMR QALGEHLQAP ALRAVLLDAE
     GPHFSFGASV DEHMPDQCAQ MLKSLHGLVR EMLDSPVPIL VALRGQCLGG GLEVAAAGNL
     LFAAPDAKFG QPEIRLGVFA PAASCLLPPR VGQACAEDLL WSGRSIDGAE GHRIGLIDVL
     AEDPEAAALR WFDEHIARLS ASSLRFAVRA ARCDSVPRIK QKLDTVEALY LEELMASHDA
     VEGLKAFLEK RSANWENR