ID   ACTX1_ANTCS             Reviewed;          32 AA.
AC   A0A6I8WFP9;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   07-OCT-2020, sequence version 1.
DT   25-MAY-2022, entry version 5.
DE   RecName: Full=Acatoxin 1 {ECO:0000312|PDB:6NK9};
DE            Short=Acatx1 {ECO:0000312|PDB:6NK9};
OS   Anthopleura cascaia (Sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Anthopleura.
OX   NCBI_TaxID=2805811;
RN   [1] {ECO:0000312|PDB:6NK9}
RP   STRUCTURE BY NMR, AND DISULFIDE BOND.
RA   Amorim G.C., Almeida F.C.L., Madio B.;
RT   "Structural features of potassium channel inhibition by Acatx1, a novel sea
RT   anemone neurotoxin.";
RL   Submitted (JAN-2019) to the PDB data bank.
CC   -!- FUNCTION: Reversibly inhibits acid-sensing ion channels (ASIC) in rat
CC       dorsal root ganglia neurons. Reversibly inhibits voltage-gated
CC       potassium channels (Kv) in rat DRG neurons.
CC       {ECO:0000250|UniProtKB:C0HJB1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:C0HJB1}.
CC       Nematocyst {ECO:0000250|UniProtKB:C0HJB1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PDB; 6NK9; NMR; -; A=1-32.
DR   PDBsum; 6NK9; -.
DR   AlphaFoldDB; A0A6I8WFP9; -.
DR   SMR; A0A6I8WFP9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Ion channel impairing toxin; Nematocyst;
KW   Neurotoxin; Proton-gated sodium channel impairing toxin; Secreted; Toxin.
FT   CHAIN           1..32
FT                   /note="Acatoxin 1"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000452543"
FT   DISULFID        1..15
FT                   /evidence="ECO:0007744|PDB:6NK9"
FT   DISULFID        8..20
FT                   /evidence="ECO:0007744|PDB:6NK9"
FT   DISULFID        14..26
FT                   /evidence="ECO:0007744|PDB:6NK9"
SQ   SEQUENCE   32 AA;  3343 MW;  AFCFCB35A4EB3BE1 CRC64;
     CGGAGAKCST KSDCCSGLWC SGSGHCYHRR YT