ID   ACTY_DICDI              Reviewed;         383 AA.
AC   Q54I79;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Centractin;
DE   AltName: Full=Actin-related protein A;
GN   Name=arpA; Synonyms=Arp1; ORFNames=DDB_G0288937;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   PROTEIN SEQUENCE OF 22-40; 46-62; 110-117; 218-228; 230-235; 243-262;
RP   93-310 AND 362-370, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=15496465; DOI=10.1073/pnas.0406923101;
RA   Gomez-Garcia M.R., Kornberg A.;
RT   "Formation of an actin-like filament concurrent with the enzymatic
RT   synthesis of inorganic polyphosphate.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:15876-15880(2004).
CC   -!- FUNCTION: Component of a multi-subunit complex, PPK2 (poly P kinase
CC       complex 2) involved in microtubule based vesicle motility. It is
CC       associated with the centrosome. PPK2 complex can synthesize a poly
CC       chain of hundreds of phosphate residues linked by ATP-like bonds.
CC       {ECO:0000269|PubMed:15496465}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000269|PubMed:15496465}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000269|PubMed:15496465}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP1 subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000126; EAL62992.1; -; Genomic_DNA.
DR   RefSeq; XP_636500.1; XM_631408.1.
DR   AlphaFoldDB; Q54I79; -.
DR   SMR; Q54I79; -.
DR   STRING; 44689.DDB0220489; -.
DR   PaxDb; Q54I79; -.
DR   EnsemblProtists; EAL62992; EAL62992; DDB_G0288937.
DR   GeneID; 8626883; -.
DR   KEGG; ddi:DDB_G0288937; -.
DR   dictyBase; DDB_G0288937; arpA.
DR   eggNOG; KOG0676; Eukaryota.
DR   HOGENOM; CLU_027965_0_2_1; -.
DR   InParanoid; Q54I79; -.
DR   OMA; YTTWTGG; -.
DR   PhylomeDB; Q54I79; -.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR   PRO; PR:Q54I79; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008976; F:polyphosphate kinase activity; IDA:dictyBase.
DR   GO; GO:0016192; P:vesicle-mediated transport; IDA:UniProtKB.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00432; ACTINS_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Direct protein sequencing;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..383
FT                   /note="Centractin"
FT                   /id="PRO_0000328041"
FT   REGION          227..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   383 AA;  43123 MW;  56828C0B0E9AD147 CRC64;
     MSSVEFSNQP VVIDNGSGVI KAGFAGQDPP SHIFQSLVGN PKYKKVMGLN IENESTYFVG
     DRINDWRGIL KLKHPMDHGI VSNWSDMERV WTYTYDQLKI QPSEHPVLLT DVPNNPRLHR
     ERAAQLFFET YNAPALYFSI PAVLSLYASG RTTGIVLDSG DGVTHVVPVF EGFALPHAIS
     RIDIAGRDIT EYLQHLLRRS GYNFKTSAEK EVVRIIKEKT CYVAHDPQKE EELLEPDSSS
     SKPVQPQYTL PDGNVIELGA ERFRAPEILF HPDIIGDESL GIHQCLDMSI RKSDLDLRKT
     FYSNIILGGG STLFQGFGDR LLNEVKKLAP KDIKIKITAP PERKYSAWMG GSILASLSTF
     KDLWVTRQEY EEDGCSVIHR KIF