ID   DCMR_METED              Reviewed;         265 AA.
AC   P45876; C7CG47;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Transcriptional repressor DcmR;
GN   Name=dcmR; OrderedLocusNames=METDI2655;
OS   Methylorubrum extorquens (strain DSM 6343 / CIP 106787 / DM4)
OS   (Methylobacterium extorquens).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=661410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1938878; DOI=10.1128/jb.173.21.6714-6721.1991;
RA   la Roche S.D., Leisinger T.;
RT   "Identification of dcmR, the regulatory gene governing expression of
RT   dichloromethane dehalogenase in Methylobacterium sp. strain DM4.";
RL   J. Bacteriol. 173:6714-6721(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6343 / CIP 106787 / DM4;
RX   PubMed=19440302; DOI=10.1371/journal.pone.0005584;
RA   Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y.,
RA   Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W.,
RA   Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E.,
RA   Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D.,
RA   Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J.,
RA   Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C.,
RA   Lidstrom M.E.;
RT   "Methylobacterium genome sequences: a reference blueprint to investigate
RT   microbial metabolism of C1 compounds from natural and industrial sources.";
RL   PLoS ONE 4:E5584-E5584(2009).
CC   -!- FUNCTION: Transcriptional repressor of the dcmA gene and of its own
CC       gene.
CC   -!- SUBUNIT: Monomer. {ECO:0000305}.
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DR   EMBL; M32346; AAB68953.1; -; Genomic_DNA.
DR   EMBL; FP103042; CAX24311.1; -; Genomic_DNA.
DR   PIR; A41327; A41327.
DR   AlphaFoldDB; P45876; -.
DR   SMR; P45876; -.
DR   EnsemblBacteria; CAX24311; CAX24311; METD_I2655.
DR   KEGG; mdi:METDI2655; -.
DR   HOGENOM; CLU_1052957_0_0_5; -.
DR   OMA; VCHYDIT; -.
DR   Proteomes; UP000008070; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR041657; HTH_17.
DR   InterPro; IPR025847; MEDS_domain.
DR   InterPro; IPR010093; SinI_DNA-bd.
DR   Pfam; PF12728; HTH_17; 1.
DR   Pfam; PF14417; MEDS; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR01764; excise; 1.
PE   4: Predicted;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..265
FT                   /note="Transcriptional repressor DcmR"
FT                   /id="PRO_0000079815"
FT   DNA_BIND        17..36
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   265 AA;  30111 MW;  72E12DDF18283273 CRC64;
     MTKERSRAAK RSEEELLDIK QAASLLNVSE ASLRRWTDSG KLPCYRVGDQ RARRFRREDL
     VAFVSVSQET ASPAQGADRP DSVKNAAKTQ VAGMDIAYHD HICAIYGRPA GRLKLSVPLL
     REGLKAGDIC FLNATQPGKA HILKVLREVY PDVHKAIKDG QLIFPALKRN KAEMLDQLEE
     MFLKATYSGE QKLRLVGDME WALSVDWSEQ EVYEYELEYN NTLGHRFPII SLCQYDVRVF
     SSKGILDALK SHEDTYKYPL RDCCI