ID   DCN1L_DICDI             Reviewed;         249 AA.
AC   Q54GP1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=DCN1-like protein 1;
DE   AltName: Full=Defective in cullin neddylation protein 1-like protein 1;
GN   ORFNames=DDB_G0290025;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May contribute to neddylation of cullin components of SCF-
CC       type E3 ubiquitin ligase complexes. Neddylation of cullins play an
CC       essential role in the regulation of SCF-type complexes activity (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; AAFI02000151; EAL62418.1; -; Genomic_DNA.
DR   RefSeq; XP_635921.1; XM_630829.1.
DR   AlphaFoldDB; Q54GP1; -.
DR   SMR; Q54GP1; -.
DR   STRING; 44689.DDB0188688; -.
DR   PaxDb; Q54GP1; -.
DR   EnsemblProtists; EAL62418; EAL62418; DDB_G0290025.
DR   GeneID; 8627442; -.
DR   KEGG; ddi:DDB_G0290025; -.
DR   dictyBase; DDB_G0290025; -.
DR   eggNOG; KOG3077; Eukaryota.
DR   HOGENOM; CLU_047042_0_1_1; -.
DR   InParanoid; Q54GP1; -.
DR   OMA; FTQTGEQ; -.
DR   PhylomeDB; Q54GP1; -.
DR   Reactome; R-DDI-8951664; Neddylation.
DR   PRO; PR:Q54GP1; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR   GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central.
DR   GO; GO:0032182; F:ubiquitin-like protein binding; IBA:GO_Central.
DR   GO; GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; IBA:GO_Central.
DR   GO; GO:0045116; P:protein neddylation; IBA:GO_Central.
DR   Gene3D; 1.10.238.200; -; 1.
DR   InterPro; IPR014764; DCN-prot.
DR   InterPro; IPR042460; DCN1-like_PONY.
DR   InterPro; IPR005176; PONY_dom.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12281; PTHR12281; 1.
DR   Pfam; PF03556; Cullin_binding; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   PROSITE; PS51229; DCUN1; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..249
FT                   /note="DCN1-like protein 1"
FT                   /id="PRO_0000330840"
FT   DOMAIN          4..49
FT                   /note="UBA-like"
FT   DOMAIN          55..245
FT                   /note="DCUN1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00574"
SQ   SEQUENCE   249 AA;  29402 MW;  EB8AF3D09BF75D76 CRC64;
     MYRLPADQKL KCTEFMSITE ATEAKAIQYL KDASWRTDAA VDNFYSNPSN FANKFDKKAI
     ETIFNKYKDS GEEQISEKLP EFVKDININD EMMELAVLWK FKTKQMGVIT KNEFMETMER
     LRCDNISSLE KQMETVRQQL SSKDLNNNSA FKEFYMFVFD LGKAENQKNV SLQMCIELWT
     IVLKSKFDNL QIWFDFLNKH HKLAISKDTW NLFLDFVKIA NDSITKYDSE GAWPVLIDEF
     VEYYKENCK