DCN1L_DROME
ID DCN1L_DROME Reviewed; 288 AA.
AC Q9VUQ8;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=DCN1-like protein;
DE AltName: Full=Defective in cullin neddylation protein 1-like protein;
GN ORFNames=CG7427;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: May contribute to neddylation of cullin components of SCF-
CC type E3 ubiquitin ligase complexes. Neddylation of cullins play an
CC essential role in the regulation of SCF-type complexes activity (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the cullin cul-5.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014296; AAF49617.2; -; Genomic_DNA.
DR EMBL; AY118412; AAM48441.1; -; mRNA.
DR RefSeq; NP_001261883.1; NM_001274954.1.
DR RefSeq; NP_648777.1; NM_140520.4.
DR AlphaFoldDB; Q9VUQ8; -.
DR SMR; Q9VUQ8; -.
DR BioGRID; 65004; 6.
DR DIP; DIP-19770N; -.
DR IntAct; Q9VUQ8; 7.
DR STRING; 7227.FBpp0297285; -.
DR PaxDb; Q9VUQ8; -.
DR PRIDE; Q9VUQ8; -.
DR DNASU; 39685; -.
DR EnsemblMetazoa; FBtr0075561; FBpp0075314; FBgn0036510.
DR EnsemblMetazoa; FBtr0331934; FBpp0304267; FBgn0036510.
DR GeneID; 39685; -.
DR KEGG; dme:Dmel_CG7427; -.
DR UCSC; CG7427-RA; d. melanogaster.
DR CTD; 39685; -.
DR FlyBase; FBgn0036510; CG7427.
DR VEuPathDB; VectorBase:FBgn0036510; -.
DR eggNOG; KOG3077; Eukaryota.
DR GeneTree; ENSGT00940000168836; -.
DR HOGENOM; CLU_047042_0_1_1; -.
DR InParanoid; Q9VUQ8; -.
DR OMA; FTQTGEQ; -.
DR OrthoDB; 1418097at2759; -.
DR PhylomeDB; Q9VUQ8; -.
DR Reactome; R-DME-8951664; Neddylation.
DR BioGRID-ORCS; 39685; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 39685; -.
DR PRO; PR:Q9VUQ8; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036510; Expressed in egg chamber and 15 other tissues.
DR ExpressionAtlas; Q9VUQ8; baseline and differential.
DR Genevisible; Q9VUQ8; DM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central.
DR GO; GO:0032182; F:ubiquitin-like protein binding; IBA:GO_Central.
DR GO; GO:0035212; P:cell competition in a multicellular organism; IMP:FlyBase.
DR GO; GO:2000436; P:positive regulation of protein neddylation; IMP:FlyBase.
DR GO; GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0045116; P:protein neddylation; ISS:UniProtKB.
DR Gene3D; 1.10.238.200; -; 1.
DR InterPro; IPR014764; DCN-prot.
DR InterPro; IPR042460; DCN1-like_PONY.
DR InterPro; IPR005176; PONY_dom.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR12281; PTHR12281; 1.
DR Pfam; PF03556; Cullin_binding; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR PROSITE; PS51229; DCUN1; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..288
FT /note="DCN1-like protein"
FT /id="PRO_0000129508"
FT DOMAIN 9..46
FT /note="UBA-like"
FT DOMAIN 56..244
FT /note="DCUN1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00574"
FT REGION 249..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 288 AA; 33695 MW; 0868AEF9241A8BDE CRC64;
MNKLKSSTHR DKVKKFISLT HTGEQTAIFC LQQNDWKFEL ASDNYFQNPE YYYRELDRKR
IEQLFMRYRD PSDPLKIGSQ GVIHFLEDLD LKPDSKLVLI IAWKFHAEVQ CEFSRDEFIN
GMCDLGIDSI DKLKTKLPIL EQELNDAGKF KDFYHFTFNY AKDPGQKGID LEMAIAYWCI
VLSGRFKFLD IWCQFLEEKH KRAISRDTWN LLLDFATNID DRMSNYDSEG AWPVLIDDFV
EWCQENDHLK EDSSPASGYQ QQSSASSSSQ KNISSAYQTS HSTNMNYG
