ID   DCN1_CANAL              Reviewed;         296 AA.
AC   Q5ADL9; A0A1D8PKM0;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Defective in cullin neddylation protein 1;
GN   Name=DCN1; OrderedLocusNames=CAALFM_C306800CA;
GN   ORFNames=CaO19.14114, CaO19.6822;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: May contribute to neddylation of cullin components of SCF-
CC       type E3 ubiquitin ligase complexes. Neddylation of cullins play an
CC       essential role in the regulation of SCF-type complexes activity (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; CP017625; AOW28686.1; -; Genomic_DNA.
DR   RefSeq; XP_019330884.1; XM_019475339.1.
DR   AlphaFoldDB; Q5ADL9; -.
DR   SMR; Q5ADL9; -.
DR   STRING; 237561.Q5ADL9; -.
DR   PRIDE; Q5ADL9; -.
DR   GeneID; 3638497; -.
DR   KEGG; cal:CAALFM_C306800CA; -.
DR   CGD; CAL0000200583; orf19.14114.
DR   VEuPathDB; FungiDB:C3_06800C_A; -.
DR   eggNOG; KOG3077; Eukaryota.
DR   HOGENOM; CLU_047042_0_0_1; -.
DR   InParanoid; Q5ADL9; -.
DR   OMA; FTQTGEQ; -.
DR   OrthoDB; 1418097at2759; -.
DR   PRO; PR:Q5ADL9; -.
DR   Proteomes; UP000000559; Chromosome 3.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR   GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central.
DR   GO; GO:0032182; F:ubiquitin-like protein binding; IBA:GO_Central.
DR   GO; GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; IBA:GO_Central.
DR   GO; GO:0045116; P:protein neddylation; IBA:GO_Central.
DR   Gene3D; 1.10.238.200; -; 1.
DR   InterPro; IPR014764; DCN-prot.
DR   InterPro; IPR042460; DCN1-like_PONY.
DR   InterPro; IPR005176; PONY_dom.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12281; PTHR12281; 1.
DR   Pfam; PF03556; Cullin_binding; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   PROSITE; PS51229; DCUN1; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..296
FT                   /note="Defective in cullin neddylation protein 1"
FT                   /id="PRO_0000129510"
FT   DOMAIN          4..41
FT                   /note="UBA-like"
FT   DOMAIN          58..291
FT                   /note="DCUN1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00574"
SQ   SEQUENCE   296 AA;  34956 MW;  6A0D627A241FA445 CRC64;
     MSSKTQLRQQ FCELTGTSNT TATKYLESVR YDLARAIDNY YNKHPNKAQV TKKPVKVKID
     DRLIQIFDKY KDSEDPNKID IEGTLTYLGD LGISPDQIES LSLALLLKSP KTGVFTRENF
     LHIWQYYQCF DIGAMSEFIT RFNKDLVNNI GGFKDISTVS DDENKSVPLK FQDLYNFTFK
     FSLETESQKF LDLDTAIEYW KLLLPIITET YSKDNKLDEE FKNHVNERVE QWFKFLTDTE
     YMTKKSISYD SWSMFYLFFK EIVLIDPIKF KDYDEMAAWP SVVDEFLEYL HDFELL