ID   DCN1_CRYNB              Reviewed;         279 AA.
AC   P0CN07; Q55UJ4; Q5KHV1;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Defective in cullin neddylation protein 1;
GN   Name=DCN1; OrderedLocusNames=CNBD1130;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: May contribute to neddylation of cullin components of SCF-
CC       type E3 ubiquitin ligase complexes. Neddylation of cullins play an
CC       essential role in the regulation of SCF-type complexes activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL21418.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAEY01000019; EAL21418.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_776065.1; XM_770972.1.
DR   AlphaFoldDB; P0CN07; -.
DR   SMR; P0CN07; -.
DR   EnsemblFungi; AAW43195; AAW43195; CND05210.
DR   EnsemblFungi; EAL21418; EAL21418; CNBD1130.
DR   GeneID; 4935502; -.
DR   KEGG; cnb:CNBD1130; -.
DR   HOGENOM; CLU_047042_0_0_1; -.
DR   Proteomes; UP000001435; Chromosome 4.
DR   Gene3D; 1.10.238.200; -; 1.
DR   InterPro; IPR014764; DCN-prot.
DR   InterPro; IPR042460; DCN1-like_PONY.
DR   InterPro; IPR005176; PONY_dom.
DR   PANTHER; PTHR12281; PTHR12281; 1.
DR   Pfam; PF03556; Cullin_binding; 1.
DR   PROSITE; PS51229; DCUN1; 1.
PE   3: Inferred from homology;
KW   Ubl conjugation pathway.
FT   CHAIN           1..279
FT                   /note="Defective in cullin neddylation protein 1"
FT                   /id="PRO_0000410057"
FT   DOMAIN          12..48
FT                   /note="UBA-like"
FT   DOMAIN          59..273
FT                   /note="DCUN1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00574"
SQ   SEQUENCE   279 AA;  31369 MW;  731C736FC49255CC CRC64;
     MASIVSPLST KDSLLVTQFR AITGTSSAEA AKYIKRYKHI EAAVDAFYNN EPAPRADPAQ
     ERKLGEIWEK FKDPSDPKLI KIDGTMELCE ELDIDPGTDA VLFCLAADLG SKATGEWEKA
     PFVAGIASYP GNIDSLPKLK AYLPTLRKKL VSDPEYFKKV YNHAFQLARG GPQSLTRSLP
     LDTAIDLWTL FFPPAFNHSP SALSHLPDNS PPQFTQPEFD LWIEFMQQKN KAVSKDTWAL
     LVDFARGIDK DFKEYDEDGA WPSMIDDFVE YVREQKRGQ