ID   DCN1_USTMA              Reviewed;         319 AA.
AC   Q4PF67; A0A0D1E6Z0;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Defective in cullin neddylation protein 1;
GN   Name=DCN1; ORFNames=UMAG_01246;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May contribute to neddylation of cullin components of SCF-
CC       type E3 ubiquitin ligase complexes. Neddylation of cullins play an
CC       essential role in the regulation of SCF-type complexes activity (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; CM003141; KIS71346.1; -; Genomic_DNA.
DR   RefSeq; XP_011387180.1; XM_011388878.1.
DR   AlphaFoldDB; Q4PF67; -.
DR   SMR; Q4PF67; -.
DR   STRING; 5270.UM01246P0; -.
DR   EnsemblFungi; KIS71346; KIS71346; UMAG_01246.
DR   GeneID; 23562336; -.
DR   KEGG; uma:UMAG_01246; -.
DR   VEuPathDB; FungiDB:UMAG_01246; -.
DR   eggNOG; KOG3077; Eukaryota.
DR   HOGENOM; CLU_047042_0_0_1; -.
DR   InParanoid; Q4PF67; -.
DR   OMA; PIVAGNK; -.
DR   OrthoDB; 1418097at2759; -.
DR   Proteomes; UP000000561; Chromosome 2.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR   GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central.
DR   GO; GO:0032182; F:ubiquitin-like protein binding; IBA:GO_Central.
DR   GO; GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; IBA:GO_Central.
DR   GO; GO:0045116; P:protein neddylation; IBA:GO_Central.
DR   Gene3D; 1.10.238.200; -; 1.
DR   InterPro; IPR014764; DCN-prot.
DR   InterPro; IPR042460; DCN1-like_PONY.
DR   InterPro; IPR005176; PONY_dom.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12281; PTHR12281; 1.
DR   Pfam; PF03556; Cullin_binding; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   PROSITE; PS51229; DCUN1; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..319
FT                   /note="Defective in cullin neddylation protein 1"
FT                   /id="PRO_0000129516"
FT   DOMAIN          7..44
FT                   /note="UBA-like"
FT   DOMAIN          67..307
FT                   /note="DCUN1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00574"
SQ   SEQUENCE   319 AA;  36204 MW;  C04AB8CE5BCDF0D4 CRC64;
     MSSAAKKEAI LRQFRQLTNA TPQDANRILK AHGYRIEPAT DAFFNNEQAQ INASISSSTL
     DRKSEREVKE RLNALFDRFR DAGADSDEED DEASQPEDRD LISIGGALKM CEALEVSPED
     VVFLPLSYYL KSASMGTFTR EGYINGWKML DLSDTIDKQK KTLEKLRQEL LDNKPLRLER
     IAQEKSNPAT ASGANKGLYE KVYEYTYAFA RREGQKSLAL ENALAFWDLV LPASPTFQRA
     GSQGTFTQAQ LDLWKRFLSE QTRGRAVSKD TWMQFLDFTK EINSDFSNHD FDAAWPSIID
     DFVLWVRDNM PASDGMDTS