ID   DCNL1_CHICK             Reviewed;         259 AA.
AC   Q5ZKU1;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DCN1-like protein 1;
DE   AltName: Full=DCUN1 domain-containing protein 1;
DE   AltName: Full=Defective in cullin neddylation protein 1-like protein 1;
GN   Name=DCUN1D1; Synonyms=DCUN1L1; ORFNames=RCJMB04_9c8;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Part of an E3 ubiquitin ligase complex for neddylation.
CC       Promotes neddylation of cullin components of E3 cullin-RING ubiquitin
CC       ligase complexes. Acts by binding to cullin-RBX1 complexes in the
CC       cytoplasm and promoting their nuclear translocation, enhancing
CC       recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and
CC       optimizing the orientation of proteins in the complex to allow
CC       efficient transfer of NEDD8 from the E2 to the cullin substrates.
CC       {ECO:0000250|UniProtKB:Q96GG9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96GG9}.
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DR   EMBL; AJ719993; CAG31652.1; -; mRNA.
DR   RefSeq; NP_001026489.1; NM_001031318.1.
DR   AlphaFoldDB; Q5ZKU1; -.
DR   SMR; Q5ZKU1; -.
DR   STRING; 9031.ENSGALP00000014300; -.
DR   PaxDb; Q5ZKU1; -.
DR   Ensembl; ENSGALT00000014316; ENSGALP00000014300; ENSGALG00000008807.
DR   GeneID; 424963; -.
DR   KEGG; gga:424963; -.
DR   CTD; 54165; -.
DR   VEuPathDB; HostDB:geneid_424963; -.
DR   eggNOG; KOG3077; Eukaryota.
DR   GeneTree; ENSGT00940000154552; -.
DR   HOGENOM; CLU_047042_0_1_1; -.
DR   InParanoid; Q5ZKU1; -.
DR   OMA; FTQTGEQ; -.
DR   OrthoDB; 1418097at2759; -.
DR   PhylomeDB; Q5ZKU1; -.
DR   PRO; PR:Q5ZKU1; -.
DR   Proteomes; UP000000539; Chromosome 9.
DR   Bgee; ENSGALG00000008807; Expressed in heart and 14 other tissues.
DR   ExpressionAtlas; Q5ZKU1; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR   GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central.
DR   GO; GO:0032182; F:ubiquitin-like protein binding; IBA:GO_Central.
DR   GO; GO:2000436; P:positive regulation of protein neddylation; ISS:UniProtKB.
DR   GO; GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; IBA:GO_Central.
DR   GO; GO:0045116; P:protein neddylation; IBA:GO_Central.
DR   Gene3D; 1.10.238.200; -; 1.
DR   InterPro; IPR014764; DCN-prot.
DR   InterPro; IPR042460; DCN1-like_PONY.
DR   InterPro; IPR005176; PONY_dom.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12281; PTHR12281; 1.
DR   Pfam; PF03556; Cullin_binding; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   PROSITE; PS51229; DCUN1; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..259
FT                   /note="DCN1-like protein 1"
FT                   /id="PRO_0000129500"
FT   DOMAIN          8..45
FT                   /note="UBA-like"
FT   DOMAIN          60..248
FT                   /note="DCUN1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00574"
SQ   SEQUENCE   259 AA;  30109 MW;  294F089666DD7708 CRC64;
     MNKLKSSQKD KVRQFMVFTQ SSEKTAVSCL SQNDWKLDVA TDNFFQNPEL YIRESVKGSL
     DRKKLEQLYN RYKDPQDENK IGIDGIQQFC DDLALDPASI TVLIIAWKFR AATQCEFSKL
     EFMDGMTELG CDSIEKLKAQ IPKMEQELKE PGRFKDFYQF TFNFAKNPGQ KGLDLEMAIA
     YWNLVLNGRF KFLDLWNKFL LEHHKRSIPK DTWNLLLDFS TMIADDMSNY DEEGAWPVLI
     DDFVEFARPQ IAGTKSTTV