ID   ACTZ_MACFA              Reviewed;         376 AA.
AC   Q4R6J9; Q4R551;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Alpha-centractin;
GN   Name=ACTR1A; ORFNames=QccE-18914, QtsA-17856;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a multi-subunit complex involved in microtubule
CC       based vesicle motility. It is associated with the centrosome (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with BCCIP. {ECO:0000250|UniProtKB:P61163}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:P85515}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250|UniProtKB:P85515}.
CC       Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P61163}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP1 subfamily. {ECO:0000305}.
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DR   EMBL; AB169184; BAE01276.1; -; mRNA.
DR   EMBL; AB169693; BAE01774.1; -; mRNA.
DR   RefSeq; NP_001272122.1; NM_001285193.1.
DR   AlphaFoldDB; Q4R6J9; -.
DR   SMR; Q4R6J9; -.
DR   STRING; 9541.XP_005566362.1; -.
DR   GeneID; 101866724; -.
DR   CTD; 10121; -.
DR   VEuPathDB; HostDB:ENSMFAG00000041926; -.
DR   eggNOG; KOG0676; Eukaryota.
DR   OMA; CIHSRFM; -.
DR   OrthoDB; 649708at2759; -.
DR   Proteomes; UP000233100; Chromosome 9.
DR   GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..376
FT                   /note="Alpha-centractin"
FT                   /id="PRO_0000260758"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:P61163"
FT   CONFLICT        140
FT                   /note="S -> P (in Ref. 1; BAE01774)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   376 AA;  42614 MW;  4A978E7AB3739436 CRC64;
     MESYDVIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHVRVMAG ALEGDIFIGP
     KAEEHRGLLS IRYPMEHGIV KDWNDMERIW QYVYSKDQLQ TFSEEHPVLL TEAPLNPRKN
     RERAAEVFFE TFNVPALFIS MQAVLSLYAT GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI
     MRIDIAGRDV SRFLRLYLRK EGYDFHSSSE FEIVKAIKER ACYLSINPQK DETLETEKAQ
     YYLPDGSTIE IGPSRFRAPE LLFRPDLIGE ESEGIHEVLV FAIQKSDMDL RRTLFSNIVL
     SGGSTLFKGF GDRLLSEVKK LAPKDVKIRI SAPQERLYST WIGGSILASL DTFKKMWVSK
     KEYEEDGARS IHRKTF