ID   DCNL3_XENLA             Reviewed;         303 AA.
AC   Q6DFA1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=DCN1-like protein 3 {ECO:0000250|UniProtKB:Q8IWE4};
DE            Short=DCNL3 {ECO:0000250|UniProtKB:Q8IWE4};
DE   AltName: Full=DCUN1 domain-containing protein 3;
DE   AltName: Full=Defective in cullin neddylation protein 1-like protein 3;
GN   Name=dcun1d3 {ECO:0000250|UniProtKB:Q8IWE4};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to the neddylation of all cullins by transferring
CC       NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to
CC       different cullin C-terminal domain-RBX complexes. At the cell membrane,
CC       can promote and as well inhibit cullins neddylation.
CC       {ECO:0000250|UniProtKB:Q8IWE4}.
CC   -!- SUBUNIT: May interact (via the DCUN1 domain) with unneddylated cullins.
CC       {ECO:0000250|UniProtKB:Q8IWE4}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IWE4}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q8IWE4}. Nucleus
CC       {ECO:0000250|UniProtKB:Q8IWE4}. Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q8IWE4}.
CC   -!- DOMAIN: The DCUN1 domain, also known as PONY domain, mediates the
CC       interaction with different cullins. {ECO:0000250|UniProtKB:Q8IWE4}.
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DR   EMBL; BC076839; AAH76839.1; -; mRNA.
DR   RefSeq; NP_001086584.1; NM_001093115.1.
DR   AlphaFoldDB; Q6DFA1; -.
DR   SMR; Q6DFA1; -.
DR   DNASU; 446419; -.
DR   GeneID; 446419; -.
DR   KEGG; xla:446419; -.
DR   CTD; 446419; -.
DR   Xenbase; XB-GENE-6256234; dcun1d3.L.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 446419; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0097602; F:cullin family protein binding; ISS:UniProtKB.
DR   GO; GO:2000435; P:negative regulation of protein neddylation; ISS:UniProtKB.
DR   GO; GO:2000436; P:positive regulation of protein neddylation; ISS:UniProtKB.
DR   GO; GO:0010564; P:regulation of cell cycle process; ISS:UniProtKB.
DR   GO; GO:2000434; P:regulation of protein neddylation; ISS:UniProtKB.
DR   Gene3D; 1.10.238.200; -; 1.
DR   InterPro; IPR014764; DCN-prot.
DR   InterPro; IPR042460; DCN1-like_PONY.
DR   InterPro; IPR005176; PONY_dom.
DR   PANTHER; PTHR12281; PTHR12281; 1.
DR   Pfam; PF03556; Cullin_binding; 1.
DR   PROSITE; PS51229; DCUN1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Lipoprotein; Membrane; Myristate; Nucleus;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..303
FT                   /note="DCN1-like protein 3"
FT                   /id="PRO_0000320053"
FT   DOMAIN          85..277
FT                   /note="DCUN1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00574"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IWE4, ECO:0000255"
SQ   SEQUENCE   303 AA;  34627 MW;  7DD352CCB4848BB0 CRC64;
     MGQCVTKCKN PSSTLGSKNG ERESSKPHKR SSSHKEEHMS ICGKASGEIL VNGTKKGDAS
     LEASQPLAVG VDTKKKEQGV GAELSSLQRI EELFRRYKDE REDAILEEGM ERFCDDLCVD
     PTEFRVLVLA WKFQAATMCK FTRREFFEGC KSINADGIES ICSQFPGLLN EAKQEDKFKD
     LYRFTFQFGL DSEEGQRSLH REIAIALWKL VFTQNKPLIL DQWLEFLTEN PSGIKGISRD
     TWNMFLNFTQ VIGPDLSNYS EDEAWPSLFD TFVEWEMERR KSEEKTDCIP CLGTDHQSRD
     EQT