DCNP1_HUMAN
ID DCNP1_HUMAN Reviewed; 244 AA.
AC Q8TF63;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Dendritic cell nuclear protein 1 {ECO:0000303|PubMed:11798177};
DE AltName: Full=Dendritic cell nuclear protein-1 {ECO:0000303|PubMed:20693543};
DE AltName: Full=Dendritic cell-associated nuclear protein {ECO:0000303|PubMed:11798177};
GN Name=DCANP1 {ECO:0000312|HGNC:HGNC:24459};
GN Synonyms=C5orf20, DCNP1 {ECO:0000303|PubMed:11798177};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11798177; DOI=10.1006/bbrc.2001.6202;
RA Masuda M., Senju S., Fujii S., Terasaki Y., Takeya M., Hashimoto S.,
RA Matsushima K., Yumoto E., Nishimura Y.;
RT "Identification and immunocytochemical analysis of DCNP1, a dendritic cell-
RT associated nuclear protein.";
RL Biochem. Biophys. Res. Commun. 290:1022-1029(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=20693543; DOI=10.1093/brain/awq207;
RA Zhou T., Wang S., Ren H., Qi X.R., Luchetti S., Kamphuis W., Zhou J.N.,
RA Wang G., Swaab D.F.;
RT "Dendritic cell nuclear protein-1, a novel depression-related protein,
RT upregulates corticotropin-releasing hormone expression.";
RL Brain 133:3069-3079(2010).
CC -!- FUNCTION: Binds with and transactivates the corticotropin-releasing
CC hormone (CRH) promoter. {ECO:0000269|PubMed:20693543}.
CC -!- INTERACTION:
CC Q8TF63; Q8N9W6-4: BOLL; NbExp=3; IntAct=EBI-10275670, EBI-11983447;
CC Q8TF63; O00571: DDX3X; NbExp=3; IntAct=EBI-10275670, EBI-353779;
CC Q8TF63; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-10275670, EBI-3957694;
CC Q8TF63; Q99750: MDFI; NbExp=7; IntAct=EBI-10275670, EBI-724076;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11798177,
CC ECO:0000269|PubMed:20693543}. Cytoplasm {ECO:0000269|PubMed:20693543}.
CC Note=Particularly on the periphery. Colocalizes with corticotropin-
CC releasing hormone (CRH) in parvocellular neurons in the paraventricular
CC nucleus. {ECO:0000269|PubMed:20693543}.
CC -!- TISSUE SPECIFICITY: Expressed in neurons of the paraventricular
CC nucleus, thalamus and occipital cortex and in glial cells (at protein
CC level). Predominantly expressed in dendritic cells. Detected in brain
CC and skeletal muscle. Highly expressed in mature dendritic cells and at
CC a lower level in immature dendritic cells. Expressed in paraventricular
CC nucleus, supraoptic nucleus and nucleus basalis of Meynert. Strongly
CC expressed in paraventricular nucleus of depressed patients compared to
CC controls. Not expressed in monocytes and B-cells.
CC {ECO:0000269|PubMed:11798177, ECO:0000269|PubMed:20693543}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB074498; BAB84585.1; -; mRNA.
DR EMBL; AC022092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069608; AAH69608.1; -; mRNA.
DR EMBL; BC069610; AAH69610.1; -; mRNA.
DR EMBL; BC074831; AAH74831.1; -; mRNA.
DR EMBL; BC074832; AAH74832.1; -; mRNA.
DR CCDS; CCDS4186.1; -.
DR PIR; JC7801; JC7801.
DR RefSeq; NP_570900.1; NM_130848.2.
DR AlphaFoldDB; Q8TF63; -.
DR BioGRID; 126768; 17.
DR IntAct; Q8TF63; 4.
DR STRING; 9606.ENSP00000421871; -.
DR iPTMnet; Q8TF63; -.
DR PhosphoSitePlus; Q8TF63; -.
DR BioMuta; DCANP1; -.
DR PaxDb; Q8TF63; -.
DR PeptideAtlas; Q8TF63; -.
DR PRIDE; Q8TF63; -.
DR Antibodypedia; 58989; 34 antibodies from 15 providers.
DR DNASU; 140947; -.
DR Ensembl; ENST00000503143.3; ENSP00000421871.1; ENSG00000251380.3.
DR GeneID; 140947; -.
DR KEGG; hsa:140947; -.
DR MANE-Select; ENST00000503143.3; ENSP00000421871.1; NM_130848.3; NP_570900.1.
DR UCSC; uc003lav.3; human.
DR CTD; 140947; -.
DR DisGeNET; 140947; -.
DR GeneCards; DCANP1; -.
DR HGNC; HGNC:24459; DCANP1.
DR HPA; ENSG00000251380; Not detected.
DR MIM; 609710; gene.
DR neXtProt; NX_Q8TF63; -.
DR OpenTargets; ENSG00000251380; -.
DR PharmGKB; PA142672373; -.
DR VEuPathDB; HostDB:ENSG00000251380; -.
DR eggNOG; ENOG502R0U5; Eukaryota.
DR GeneTree; ENSGT00550000075626; -.
DR HOGENOM; CLU_1137705_0_0_1; -.
DR OMA; KHLACSF; -.
DR OrthoDB; 1328851at2759; -.
DR PathwayCommons; Q8TF63; -.
DR SignaLink; Q8TF63; -.
DR BioGRID-ORCS; 140947; 4 hits in 988 CRISPR screens.
DR GenomeRNAi; 140947; -.
DR Pharos; Q8TF63; Tbio.
DR PRO; PR:Q8TF63; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8TF63; protein.
DR Bgee; ENSG00000251380; Expressed in granulocyte and 27 other tissues.
DR Genevisible; Q8TF63; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016604; C:nuclear body; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0031223; P:auditory behavior; IGI:CAFA.
DR GO; GO:0090102; P:cochlea development; IGI:CAFA.
DR GO; GO:0090103; P:cochlea morphogenesis; IGI:CAFA.
DR GO; GO:0097094; P:craniofacial suture morphogenesis; IGI:CAFA.
DR GO; GO:0048806; P:genitalia development; IGI:CAFA.
DR GO; GO:0035112; P:genitalia morphogenesis; IGI:CAFA.
DR GO; GO:1905748; P:hard palate morphogenesis; IGI:CAFA.
DR GO; GO:0048839; P:inner ear development; IGI:CAFA.
DR GO; GO:0042472; P:inner ear morphogenesis; IGI:CAFA.
DR GO; GO:0098583; P:learned vocalization behavior; IGI:CAFA.
DR GO; GO:0071626; P:mastication; IGI:CAFA.
DR GO; GO:1901078; P:negative regulation of relaxation of muscle; IGI:CAFA.
DR GO; GO:1905747; P:negative regulation of saliva secretion; IGI:CAFA.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IGI:CAFA.
DR GO; GO:0030432; P:peristalsis; IGI:CAFA.
DR GO; GO:0048634; P:regulation of muscle organ development; IGI:CAFA.
DR GO; GO:0007356; P:thorax and anterior abdomen determination; IGI:CAFA.
DR GO; GO:0021559; P:trigeminal nerve development; IGI:CAFA.
DR GO; GO:0021650; P:vestibulocochlear nerve formation; IGI:CAFA.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..244
FT /note="Dendritic cell nuclear protein 1"
FT /id="PRO_0000229790"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 75
FT /note="T -> P (in dbSNP:rs1031844)"
FT /id="VAR_025758"
FT VARIANT 97
FT /note="N -> D (in dbSNP:rs12520809)"
FT /id="VAR_025759"
SQ SEQUENCE 244 AA; 26704 MW; 803125CEFA61B9F8 CRC64;
MHYGAATHIQ NSRSHGLETV PGHQRLERGA GGETPEFPGC HSPAPPENFG NELLPLSAPL
QGLSEGLYPP GRNKTLPAGV LREGAVQFLH RGLCNSNLSS EASARPSGTQ DELHSSRRKT
GQTRREGARK HLVCSFRLYP FTVHTVSPGN SHLALYQVFK AVKLCPSETS FFLSRKSLKS
SDPWHPPSLS PNSWNRQAGF RAWSSHLISL SLTCSDSQSR RVSSSQQPPL HSLSSHRRAA
HVPE
