ID   ACTZ_NEUCR              Reviewed;         380 AA.
AC   P38673; Q01258; Q7RVD0;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=Actin-like protein;
DE   AltName: Full=Centractin;
GN   Name=ro-4; ORFNames=2E4.190, NCU04247;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=7929559; DOI=10.1083/jcb.127.1.139;
RA   Plamann M., Minke P.F., Tinsley J.H., Bruno K.S.;
RT   "Cytoplasmic dynein and actin-related protein Arp1 are required for normal
RT   nuclear distribution in filamentous fungi.";
RL   J. Cell Biol. 127:139-149(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=7603438; DOI=10.1007/bf00290350;
RA   Robb M.J., Wilson M.A., Vierula P.J.;
RT   "A fungal actin-related protein involved in nuclear migration.";
RL   Mol. Gen. Genet. 247:583-590(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in nuclear migration. May function as a component of
CC       the dynactin complex which activates force generation by cytoplasmic
CC       dynein.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP1 subfamily. {ECO:0000305}.
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DR   EMBL; L31505; AAA64907.1; -; Genomic_DNA.
DR   EMBL; U14008; AAB02296.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL451022; CAC18320.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA32002.1; -; Genomic_DNA.
DR   PIR; A54802; A54802.
DR   PIR; T46655; T46655.
DR   RefSeq; XP_961238.1; XM_956145.2.
DR   AlphaFoldDB; P38673; -.
DR   SMR; P38673; -.
DR   STRING; 5141.EFNCRP00000003893; -.
DR   EnsemblFungi; EAA32002; EAA32002; NCU04247.
DR   GeneID; 3877401; -.
DR   KEGG; ncr:NCU04247; -.
DR   VEuPathDB; FungiDB:NCU04247; -.
DR   HOGENOM; CLU_027965_0_2_1; -.
DR   InParanoid; P38673; -.
DR   OMA; YTTWTGG; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..380
FT                   /note="Actin-like protein"
FT                   /id="PRO_0000089064"
SQ   SEQUENCE   380 AA;  42382 MW;  360130BB4964CC35 CRC64;
     MTDSLHNAPI VLDNGSGTIR AGFAGDDVPK CHFPSFVGRP KHLRVLAGAL EGEVFIGQKA
     ASELRGLLKI RYPLEHGIVT DWDDMEKIWA YVYDEGLKTL SEEHPVLLTE PPLNPRANRD
     TAAQILFETF NVPALYTSIQ AVLSLYASGR TTGVVLDSGD GVSHAVPVYQ GFTVPNSIRR
     IDVAGRDVTE YLQTLLRKSG YVFHTSAEKE VVRLIKESVT YVAHDPRKEE KEWAAAKMDP
     AKIAEYVLPD GNKLKIGAER FRAPEILFDP EIIGLEYPGV HQIVVDSINR TDLDLRRDLY
     SNIVLSGGST LTKGFGDRLL TEVQKLAVKD MRIKIFAPPE RKYSTWIGGS ILAGLSTFRK
     MWVSIDDWHE NPDIIHTKFT