DCOR_LACS3
ID DCOR_LACS3 Reviewed; 731 AA.
AC P43099;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Inducible ornithine decarboxylase;
DE Short=ODC;
DE EC=4.1.1.17;
GN Name=odcI;
OS Lactobacillus sp. (strain 30a).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus; unclassified Lactobacillus.
OX NCBI_TaxID=1593;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=7961515; DOI=10.1128/jb.176.23.7391-7394.1994;
RA Hackert M.L., Carroll D.W., Davidson L., Kim S.-O., Momany C., Vaaler G.L.,
RA Zhang L.;
RT "Sequence of ornithine decarboxylase from Lactobacillus sp. strain 30a.";
RL J. Bacteriol. 176:7391-7394(1994).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
RX PubMed=7563080; DOI=10.1006/jmbi.1995.0526;
RA Momany C., Ernst S., Gosh R., Chang N.-L., Hackert M.L.;
RT "Crystallographic structure of a PLP-dependent ornithine decarboxylase from
RT Lactobacillus 30a to 3.0-A resolution.";
RL J. Mol. Biol. 252:643-655(1995).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
RX PubMed=10666573; DOI=10.1107/s0907444999010756;
RA Vitali J., Carroll D., Chaudhry R.G., Hackert M.L.;
RT "Three-dimensional structure of the Gly121Tyr dimeric form of ornithine
RT decarboxylase from Lactobacillus 30a.";
RL Acta Crystallogr. D 55:1978-1985(1999).
RN [4]
RP DISCUSSION OF SEQUENCE.
RX PubMed=7663340; DOI=10.1002/pro.5560040504;
RA Momany C., Gosh R., Hackert M.L.;
RT "Structural motifs for pyridoxal-5'-phosphate binding in decarboxylases: an
RT analysis based on the crystal structure of the Lactobacillus 30a ornithine
RT decarboxylase.";
RL Protein Sci. 4:849-854(1995).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + L-ornithine = CO2 + putrescine; Xref=Rhea:RHEA:22964,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:46911,
CC ChEBI:CHEBI:326268; EC=4.1.1.17;
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC -!- SUBUNIT: Dodecamer.
CC -!- INDUCTION: By ornithine.
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-I family.
CC {ECO:0000305}.
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DR EMBL; U11816; AAA64830.1; -; Genomic_DNA.
DR PIR; A55229; A55229.
DR PDB; 1C4K; X-ray; 2.70 A; A=2-731.
DR PDB; 1ORD; X-ray; 3.00 A; A/B=2-731.
DR PDBsum; 1C4K; -.
DR PDBsum; 1ORD; -.
DR AlphaFoldDB; P43099; -.
DR SMR; P43099; -.
DR DrugBank; DB04137; Guanosine-5'-Triphosphate.
DR BRENDA; 4.1.1.17; 13668.
DR SABIO-RK; P43099; -.
DR EvolutionaryTrace; P43099; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004586; F:ornithine decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR CDD; cd00615; Orn_deC_like; 1.
DR Gene3D; 3.40.50.220; -; 1.
DR Gene3D; 3.40.640.10; -; 1.
DR Gene3D; 3.90.1150.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR005308; OKR_de-COase_N.
DR InterPro; IPR011193; Orn/lys/arg_de-COase.
DR InterPro; IPR000310; Orn/Lys/Arg_deCO2ase_major_dom.
DR InterPro; IPR027464; Ornithine_deCO2ase_N.
DR InterPro; IPR008286; Prn/Lys/Arg_de-COase_C.
DR InterPro; IPR036633; Prn/Lys/Arg_de-COase_C_sf.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR Pfam; PF01276; OKR_DC_1; 1.
DR Pfam; PF03711; OKR_DC_1_C; 1.
DR Pfam; PF03709; OKR_DC_1_N; 1.
DR PIRSF; PIRSF009393; Orn_decarb; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR SUPFAM; SSF53383; SSF53383; 1.
DR SUPFAM; SSF55904; SSF55904; 1.
DR PROSITE; PS00703; OKR_DC_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Decarboxylase; Direct protein sequencing; Lyase;
KW Pyridoxal phosphate.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..731
FT /note="Inducible ornithine decarboxylase"
FT /id="PRO_0000201137"
FT MOD_RES 356
FT /note="N6-(pyridoxal phosphate)lysine"
FT STRAND 6..9
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 11..16
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 27..29
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 31..40
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 44..51
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 59..64
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 66..68
FT /evidence="ECO:0007829|PDB:1ORD"
FT HELIX 71..74
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 79..82
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 92..107
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 110..119
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 127..129
FT /evidence="ECO:0007829|PDB:1C4K"
FT TURN 130..136
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 137..139
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 141..150
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 153..156
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 164..166
FT /evidence="ECO:0007829|PDB:1C4K"
FT TURN 169..172
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 175..186
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 190..197
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 198..210
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 216..220
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 225..231
FT /evidence="ECO:0007829|PDB:1C4K"
FT TURN 232..235
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 238..242
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 244..246
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 252..255
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 257..259
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 262..268
FT /evidence="ECO:0007829|PDB:1C4K"
FT TURN 269..271
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 274..277
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 283..291
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 295..298
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 300..307
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 308..310
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 311..317
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 323..325
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 328..333
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 347..352
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 354..357
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 365..370
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 372..374
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 375..379
FT /evidence="ECO:0007829|PDB:1ORD"
FT HELIX 383..393
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 400..413
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 415..438
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 442..447
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 449..451
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 456..458
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 461..464
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 468..471
FT /evidence="ECO:0007829|PDB:1C4K"
FT TURN 478..480
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 490..492
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 496..500
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 502..505
FT /evidence="ECO:0007829|PDB:1C4K"
FT TURN 506..509
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 518..527
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 533..535
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 537..543
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 550..568
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 573..576
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 578..581
FT /evidence="ECO:0007829|PDB:1C4K"
FT TURN 585..587
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 593..605
FT /evidence="ECO:0007829|PDB:1C4K"
FT TURN 606..608
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 609..615
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 619..621
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 624..627
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 629..637
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 641..645
FT /evidence="ECO:0007829|PDB:1C4K"
FT TURN 646..648
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 652..656
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 658..660
FT /evidence="ECO:0007829|PDB:1C4K"
FT TURN 661..663
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 676..691
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 699..707
FT /evidence="ECO:0007829|PDB:1C4K"
FT STRAND 710..718
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 720..724
FT /evidence="ECO:0007829|PDB:1C4K"
FT HELIX 727..729
FT /evidence="ECO:0007829|PDB:1C4K"
SQ SEQUENCE 731 AA; 82688 MW; 3652214455C956AF CRC64;
MSSSLKIAST QEARQYFDTD RVVVDAVGSD FTDVGAVIAM DYETDVIDAA DATKFGIPVF
AVTKDAQAIS ADELKKIFHI IDLENKFDAT VNAREIETAV NNYEDSILPP FFKSLKEYVS
RGLIQFDCPG HQGGQYYRKH PAGREFYDFF GETVFRADLC NADVALGDLL IHEGPAVAAE
KHAARVYNAD KTYFVLGGSS NANNTVTSAL VSNGDLVLFD RNNHKSVYNS ALAMAGGRPV
YLQTNRNPYG FIGGIYDSDF DEKKIRELAA KVDPERAKWK RPFRLAVIQL GTYDGTIYNA
HEVVKRIGHL CDYIEFDSAW VGYEQFIPMM RNSSPLLIDD LGPEDPGIIV VQSVHKQQAG
FSQTSQIHKK DSHIKGQLRY CDHKHFNNSF NLFMSTSPFY PMYAALDVNA AMQEGEAGRK
LWHDLLITTI EARKKLIKAG SMFRPFVPPV VNGKKWEDGD TEDMANNIDY WRFEKGAKWH
AYEGYGDNQY YVDPNKFMLT TPGINPETGD YEDFGVPATI VANYLRDHGI IPEKSDLNSI
LFLMTPAETP AKMNNLITQL LQLQRLIEED APLKQVLPSI YAANEERYNG YTIRELCQEL
HDFYKNNNTF TYQKRLFLRE FFPEQGMLPY EARQEFIRNH NKLVPLNKIE GEIALEGALP
YPPGVFCVAP GEKWSETAVK YFTILQDGIN NFPGFAPEIQ GVYFKQEGDK VVAYGEVYDA
EVAKNDDRYN N
