ID   DCP1_ASHGO              Reviewed;         193 AA.
AC   Q74Z05;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=mRNA-decapping enzyme subunit 1;
GN   Name=DCP1; OrderedLocusNames=AGR402C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the decapping complex necessary for the
CC       degradation of mRNAs, both in normal mRNA turnover and in nonsense-
CC       mediated mRNA decay. Removes the 7-methyl guanine cap structure from
CC       mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP.
CC       Decapping is the major pathway of mRNA degradation in yeast. It occurs
CC       through deadenylation, decapping and subsequent 5' to 3' exonucleolytic
CC       decay of the transcript body (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the decapping complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250}. Note=Is
CC       concentrated in several cytoplasmic foci called P bodies (or
CC       cytoplasmic processing bodies) which represent sites of mRNA decapping
CC       and 5' to 3' exonucleotidic decay. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DCP1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016820; AAS54892.1; -; Genomic_DNA.
DR   RefSeq; NP_987068.1; NM_212130.1.
DR   AlphaFoldDB; Q74Z05; -.
DR   SMR; Q74Z05; -.
DR   STRING; 33169.AAS54892; -.
DR   EnsemblFungi; AAS54892; AAS54892; AGOS_AGR402C.
DR   GeneID; 4623372; -.
DR   KEGG; ago:AGOS_AGR402C; -.
DR   eggNOG; KOG2868; Eukaryota.
DR   HOGENOM; CLU_113008_0_0_1; -.
DR   InParanoid; Q74Z05; -.
DR   OMA; IWIHTVA; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0098562; C:cytoplasmic side of membrane; IEA:EnsemblFungi.
DR   GO; GO:0098745; C:Dcp1-Dcp2 complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:EnsemblFungi.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IBA:GO_Central.
DR   GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   GO; GO:0043085; P:positive regulation of catalytic activity; IEA:InterPro.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR010334; Dcp1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR16290; PTHR16290; 1.
DR   Pfam; PF06058; DCP1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; Nonsense-mediated mRNA decay;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..193
FT                   /note="mRNA-decapping enzyme subunit 1"
FT                   /id="PRO_0000232997"
SQ   SEQUENCE   193 AA;  22329 MW;  0CFD260A11663CAE CRC64;
     MTTARDNSAT TLELYRKTLN FNVIGRYDPK IKQLLFHTPH ATVYKWEAGE NKWNKLEYQG
     VLAIYLRDVR EQAELPVPHQ EASAGAEGRC GEVLSGRDIY NYALIVLNRI NPENFSIAIA
     PNSVVNKRRL FSPEENVQQP LEPMDVEVKD ELVIIKNLRK EVYGIWIHTP TDRQNIYDLL
     KYLLENEPKD SFA