DCP5L_ARATH
ID DCP5L_ARATH Reviewed; 571 AA.
AC Q9FH77;
DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Decapping 5-like protein;
GN Name=DCP5-L; OrderedLocusNames=At5g45330; ORFNames=K9E15.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=16244158; DOI=10.1104/pp.105.063479;
RA Xiao Y.-L., Smith S.R., Ishmael N., Redman J.C., Kumar N., Monaghan E.L.,
RA Ayele M., Haas B.J., Wu H.C., Town C.D.;
RT "Analysis of the cDNAs of hypothetical genes on Arabidopsis chromosome 2
RT reveals numerous transcript variants.";
RL Plant Physiol. 139:1323-1337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis cDNA clones.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION.
RX PubMed=19855049; DOI=10.1105/tpc.109.070078;
RA Xu J., Chua N.-H.;
RT "Arabidopsis decapping 5 is required for mRNA decapping, P-body formation,
RT and translational repression during postembryonic development.";
RL Plant Cell 21:3270-3279(2009).
CC -!- FUNCTION: As a component of the decapping complex, involved in the
CC degradation of mRNAs. Promotes P-body formation. Translational
CC repressor (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Component of the decapping complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LSM14 family. {ECO:0000305}.
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DR EMBL; AB020744; BAB10254.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95233.1; -; Genomic_DNA.
DR EMBL; AY735697; AAU44567.1; -; mRNA.
DR EMBL; AY954874; AAX55200.1; -; mRNA.
DR EMBL; BT022113; AAY34174.1; -; mRNA.
DR RefSeq; NP_199346.1; NM_123901.4.
DR AlphaFoldDB; Q9FH77; -.
DR SMR; Q9FH77; -.
DR STRING; 3702.AT5G45330.1; -.
DR iPTMnet; Q9FH77; -.
DR PaxDb; Q9FH77; -.
DR PRIDE; Q9FH77; -.
DR ProteomicsDB; 224219; -.
DR EnsemblPlants; AT5G45330.1; AT5G45330.1; AT5G45330.
DR GeneID; 834569; -.
DR Gramene; AT5G45330.1; AT5G45330.1; AT5G45330.
DR KEGG; ath:AT5G45330; -.
DR Araport; AT5G45330; -.
DR TAIR; locus:2158470; AT5G45330.
DR eggNOG; KOG1073; Eukaryota.
DR HOGENOM; CLU_028438_0_0_1; -.
DR InParanoid; Q9FH77; -.
DR OrthoDB; 1569369at2759; -.
DR PhylomeDB; Q9FH77; -.
DR PRO; PR:Q9FH77; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FH77; baseline and differential.
DR GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; ISS:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0017148; P:negative regulation of translation; ISS:UniProtKB.
DR GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR GO; GO:0010606; P:positive regulation of cytoplasmic mRNA processing body assembly; ISS:UniProtKB.
DR GO; GO:0034063; P:stress granule assembly; IBA:GO_Central.
DR CDD; cd01736; LSm14_N; 1.
DR InterPro; IPR025762; DFDF.
DR InterPro; IPR019050; FDF_dom.
DR InterPro; IPR025761; FFD_box.
DR InterPro; IPR025609; Lsm14-like_N.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR025768; TFG_box.
DR Pfam; PF09532; FDF; 1.
DR Pfam; PF12701; LSM14; 1.
DR SMART; SM01199; FDF; 1.
DR SMART; SM01271; LSM14; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
DR PROSITE; PS51512; DFDF; 1.
DR PROSITE; PS51513; FFD; 1.
DR PROSITE; PS51536; TFG; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; mRNA processing; Reference proteome; Repressor;
KW Translation regulation.
FT CHAIN 1..571
FT /note="Decapping 5-like protein"
FT /id="PRO_0000418340"
FT DOMAIN 419..455
FT /note="DFDF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00845"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 474..489
FT /note="FFD box"
FT MOTIF 498..518
FT /note="TFG box"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 571 AA; 61799 MW; EACBFB2BC8706D43 CRC64;
MASESSQSSS PSSSQPPSSV PSPSPGNNVG DTFIGSFISL ISKYEIRYEG ILYHLNVQDS
TLGLKNVRSC GTEGRKKDGP QIPPCDKVYD YILFRGSDIK DLQVNPSPSA QSRQEIQSEQ
DVNQSPHSRP AMTMSSPISG YDSGYGLGRG SQWINTPALS SKPVPVTQHS SVPLSFQPPS
ANAGSLTESP VSLIDSTQSN AGSSMPIPSF VQGNKFASSG VPLGMMQKPV SSSSTIPNGP
QIIDYFSSPI MGLVDDSSQV VTRSPDVSSN QSYSSNPSPL GQTQLHTPPG LASVSSNLSP
PSEAQLSAPN IQKIYPSAPQ AIGKVVYDPQ SNHPHRSIPH ELPAVASNSA PVIPGPLSKS
PESFFDMDPS LQSRQQMVYR GQEMFAATNP ASANVPSQSF APRNHAPLLP LPVSAHQSRI
PSSSIEYTEE FDFEAMNEKF KKSELWGYLG RNNQRNQNDY GEETAIEPNA EGKPAYNKDD
FFDTISCNQL DRVARSGQQH NQFPEHMRQV PEAFGNNFQR PPPLQPGQGA YLAAQTNYRG
GYHNNNNNNY YSNSGYGYYS GGRGRGRNTH F
