DCP66_CAEEL
ID DCP66_CAEEL Reviewed; 724 AA.
AC G5ED89; G5ECM2;
DT 02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Transcription factor dcp-66 {ECO:0000305};
DE AltName: Full=Deacetylase complex protein dcp-66 {ECO:0000312|WormBase:C26C6.5b};
GN Name=dcp-66 {ECO:0000312|WormBase:C26C6.5b};
GN ORFNames=C26C6.5 {ECO:0000312|WormBase:C26C6.5b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=16159881; DOI=10.1074/jbc.m505701200;
RA Zhao Z., Fang L., Chen N., Johnsen R.C., Stein L., Baillie D.L.;
RT "Distinct regulatory elements mediate similar expression patterns in the
RT excretory cell of Caenorhabditis elegans.";
RL J. Biol. Chem. 280:38787-38794(2005).
CC -!- FUNCTION: Transcription factor which binds to the 5'-CCATACATTA-3'
CC motif found in the promoter region of pgp-12 and activates its
CC expression in the excretory cell. {ECO:0000269|PubMed:16159881}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b {ECO:0000312|WormBase:C26C6.5b};
CC IsoId=G5ED89-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:C26C6.5a};
CC IsoId=G5ED89-2; Sequence=VSP_060799;
CC -!- TISSUE SPECIFICITY: Expressed at low levels in excretory cell, pharynx,
CC vulva, and posterior neurons in adults (PubMed:16159881). Strongly
CC expressed in the excretory cell and more weakly in the pharynx in larva
CC (PubMed:16159881). Embryonic expression in the excretory cell
CC (PubMed:16159881). {ECO:0000269|PubMed:16159881}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryo, larva and adult.
CC {ECO:0000269|PubMed:16159881}.
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DR EMBL; BX284601; CAA96601.3; -; Genomic_DNA.
DR EMBL; BX284601; CAD56560.3; -; Genomic_DNA.
DR RefSeq; NP_492111.3; NM_059710.5. [G5ED89-2]
DR RefSeq; NP_871831.3; NM_182031.4. [G5ED89-1]
DR AlphaFoldDB; G5ED89; -.
DR IntAct; G5ED89; 18.
DR STRING; 6239.C26C6.5b; -.
DR EPD; G5ED89; -.
DR PaxDb; G5ED89; -.
DR EnsemblMetazoa; C26C6.5a.1; C26C6.5a.1; WBGene00000938. [G5ED89-2]
DR EnsemblMetazoa; C26C6.5b.1; C26C6.5b.1; WBGene00000938. [G5ED89-1]
DR GeneID; 172507; -.
DR KEGG; cel:CELE_C26C6.5; -.
DR CTD; 172507; -.
DR WormBase; C26C6.5a; CE47783; WBGene00000938; dcp-66.
DR WormBase; C26C6.5b; CE47789; WBGene00000938; dcp-66.
DR eggNOG; KOG3740; Eukaryota.
DR GeneTree; ENSGT00390000004097; -.
DR HOGENOM; CLU_385068_0_0_1; -.
DR InParanoid; G5ED89; -.
DR OMA; RLPNLAM; -.
DR OrthoDB; 1046568at2759; -.
DR Reactome; R-CEL-3214815; HDACs deacetylate histones.
DR Reactome; R-CEL-8943724; Regulation of PTEN gene transcription.
DR SignaLink; G5ED89; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000938; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; G5ED89; baseline.
DR GO; GO:0005634; C:nucleus; IMP:UniProtKB.
DR GO; GO:0016581; C:NuRD complex; IMP:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IMP:UniProtKB.
DR GO; GO:0006325; P:chromatin organization; IMP:UniProtKB.
DR GO; GO:0034514; P:mitochondrial unfolded protein response; IMP:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR InterPro; IPR040386; P66.
DR PANTHER; PTHR13455; PTHR13455; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Coiled coil; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..724
FT /note="Transcription factor dcp-66"
FT /id="PRO_0000451520"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 186..216
FT /evidence="ECO:0000255"
FT COMPBIAS 68..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 501..503
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_060799"
SQ SEQUENCE 724 AA; 79470 MW; A978886A234F38F7 CRC64;
MAQVQQVPSS PMNGIPEKNG NGLSIEESAS TAVAALAHIQ NGAVLFHGTP TKDLNGASTS
IDTDDLQLSP SDLRRRSTRA SALKAQEKIK LKDDIVQGPQ KRANDDDDME DEELGDEINE
QSAPKKRRLE NGKEFDQTCF RFGLRANNEG EVYAMTDESE NSSIHESEME VVRYHYEKMK
NKEPDEEQLR ERLNMRREAE NQLREEEAKL LVLRKMKDSQ TRAITKLAAE TKAADLAEAT
SAAYKPAVAT NGKSVTNGKN SMIESNNKTM NGLKNLSIPQ QLELLQKLSS QSPAAKQAYI
MAKKNPAQTT QLFQQLITIN NQNLQKQKEL SAAETNASAS ASPAVQQSQQ AQQPQQAQIT
QSKLLNQQTP AQRIQAARLA FRAQADKQLT TIPTQKSQPH DITFLPNPNA SAFLALHGLD
LVVQHVLKDR SNETPYAGPS YECEECKTEC AHTWKAIGST QDDLHLYCEN CVRSAQKRKN
RTDQTALLKR AFQKITAQEK LLQEFEKKIA EGQLEQYAEA KAAAPATSQT IPTSSTATVS
SIPLVPRLPQ IPSSTGSSTP TQAVKTSTPI HSTPKSSSSS AKKTAAQLQQ QSMQGMNQLF
STAMLRNNPQ MQQMLQMYQA LAMGGGAANM ANNQMAMLFQ AQAMQAAQAQ VARAQAAKAQ
AAQAQAAQAQ AQAQANREAN QQSMLIQALM SNGQVNVQAL QQLQKLTPEQ QKALIEVVKR
QTRK
