DCR1_DICDI
ID DCR1_DICDI Reviewed; 920 AA.
AC Q86KS1; Q54Z59;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=DNA cross-link repair 1 protein;
GN Name=dclre1; ORFNames=DDB_G0277755;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May be required for DNA interstrand cross-link repair.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000305}.
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DR EMBL; AAFI02000022; EAL68551.1; -; Genomic_DNA.
DR RefSeq; XP_642494.1; XM_637402.1.
DR AlphaFoldDB; Q86KS1; -.
DR SMR; Q86KS1; -.
DR STRING; 44689.DDB0232254; -.
DR PaxDb; Q86KS1; -.
DR EnsemblProtists; EAL68551; EAL68551; DDB_G0277755.
DR GeneID; 8621205; -.
DR KEGG; ddi:DDB_G0277755; -.
DR dictyBase; DDB_G0277755; dclre1.
DR eggNOG; KOG1361; Eukaryota.
DR HOGENOM; CLU_316990_0_0_1; -.
DR InParanoid; Q86KS1; -.
DR OMA; DYSAPKD; -.
DR PRO; PR:Q86KS1; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IC:dictyBase.
DR GO; GO:0035312; F:5'-3' exodeoxyribonuclease activity; IBA:GO_Central.
DR GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:dictyBase.
DR GO; GO:0036297; P:interstrand cross-link repair; IBA:GO_Central.
DR GO; GO:0031848; P:protection from non-homologous end joining at telomere; IBA:GO_Central.
DR Gene3D; 3.60.15.10; -; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR Pfam; PF07522; DRMBL; 1.
DR SUPFAM; SSF56281; SSF56281; 1.
PE 3: Inferred from homology;
KW Coiled coil; DNA damage; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..920
FT /note="DNA cross-link repair 1 protein"
FT /id="PRO_0000376874"
FT REGION 62..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 214..241
FT /evidence="ECO:0000255"
FT COILED 702..746
FT /evidence="ECO:0000255"
FT COMPBIAS 84..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 105407 MW; 8136939FDA25A164 CRC64;
MSDDEDDINL YITRSKNNEN KKTNKNRLID NNIQKTKTTT AVLTTRTTTT TTTTTASTQL
KWDYGDEDDD DYSAPKDIDE EQSSKQFNYQ NNQIVVKQDH DDYSAPKDMD EEQSSRQFNY
QNDQTLVKQD DDHDDYNEPK DIDSQSLIDE DCDFEFDNSD FFFDDGTTNN NDNNNKNNKN
NNNNNNNNNN NNNYNNNNNK NYKRKYYQSY NNSNNINNNN NNNNDKFEKR LSDLKKTGKE
EAKKRGYQVR KTPTKEKKIP PSFKVIDGTN FLVDGFQYKS EDFTHYFLTH FHSDHYVGIT
KTWSFGNIYC TEETGKLVSH KLGVDQRYIV KCEWNKLIEI QGVKVAFLDS NHCPGSALIL
FIIPLRNKDG EIIGEESILH TGDFRYNQSM NNYPLLKGRT ISKLYLDNTY CDPQYVFPPQ
PEIIKQVASI VRKENDGETL FLFGTYVIGK ERILLEIAKQ EGKPVHVSNE KYAILCCLST
CLDINKFTTN ELITPFRAVT MSMLSYHNML SLLDSSNNKY KRVIGFRPTG WTQAKKSITY
LNRGPTTFYS VAYSEHSSFN ELRDCIDHFR PTQIIPTVDC DSPIKVKNIL AHFSDLYEKK
KQLTIASFFS AQPVTNFFQS FFKSKSEPII DEDNKKLIPI TTTTTTNINT LTATDTTTTK
IKTSNTLIKD EFTDDLIWDC SDDLISDRKL LTQSDNSSAL CKIEKEENFN DLSENNNNSN
NNNNNNNNNN NNNNNNNNNN NNNNKLIIEN DIKEEIIDFD DPVFISQQKW IEKQIYNNNN
NSNNNNFTTP TKTNGNLSNN AKLNLTPTQT QTQTPTQNNK KQKTTNVSPT SYNSNNSSQQ
SGLKRSKSDP NVKKNQLQTS QPPSQSLITS FFQKCASPTS LFSATPPTPS ITTTSNQSTK
NKNSTTTTST STSNNKPFKN
