DCST2_HUMAN
ID DCST2_HUMAN Reviewed; 773 AA.
AC Q5T1A1; Q2M2R2; Q8N810; Q96M03;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=DC-STAMP domain-containing protein 2;
GN Name=DCST2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 170-773 (ISOFORM 1).
RC TISSUE=Testis, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-744 (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5T1A1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T1A1-2; Sequence=VSP_023408, VSP_023409;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05065.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK057496; BAB71511.1; -; mRNA.
DR EMBL; AK097468; BAC05065.1; ALT_SEQ; mRNA.
DR EMBL; AL451085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC111794; AAI11795.1; -; mRNA.
DR CCDS; CCDS1082.2; -. [Q5T1A1-1]
DR RefSeq; NP_653223.2; NM_144622.2. [Q5T1A1-1]
DR AlphaFoldDB; Q5T1A1; -.
DR BioGRID; 126069; 2.
DR STRING; 9606.ENSP00000357409; -.
DR GlyGen; Q5T1A1; 3 sites.
DR iPTMnet; Q5T1A1; -.
DR PhosphoSitePlus; Q5T1A1; -.
DR BioMuta; DCST2; -.
DR DMDM; 143975954; -.
DR MassIVE; Q5T1A1; -.
DR PaxDb; Q5T1A1; -.
DR PeptideAtlas; Q5T1A1; -.
DR PRIDE; Q5T1A1; -.
DR Antibodypedia; 68362; 9 antibodies from 4 providers.
DR DNASU; 127579; -.
DR Ensembl; ENST00000368424.4; ENSP00000357409.3; ENSG00000163354.15. [Q5T1A1-1]
DR Ensembl; ENST00000485982.5; ENSP00000436964.1; ENSG00000163354.15. [Q5T1A1-2]
DR GeneID; 127579; -.
DR KEGG; hsa:127579; -.
DR MANE-Select; ENST00000368424.4; ENSP00000357409.3; NM_144622.3; NP_653223.2.
DR UCSC; uc001fgm.4; human. [Q5T1A1-1]
DR CTD; 127579; -.
DR DisGeNET; 127579; -.
DR GeneCards; DCST2; -.
DR HGNC; HGNC:26562; DCST2.
DR HPA; ENSG00000163354; Tissue enhanced (retina, skin).
DR MIM; 619861; gene.
DR neXtProt; NX_Q5T1A1; -.
DR OpenTargets; ENSG00000163354; -.
DR PharmGKB; PA142672006; -.
DR VEuPathDB; HostDB:ENSG00000163354; -.
DR eggNOG; KOG3726; Eukaryota.
DR GeneTree; ENSGT00940000153269; -.
DR HOGENOM; CLU_015030_2_0_1; -.
DR InParanoid; Q5T1A1; -.
DR OMA; QVFCIIP; -.
DR OrthoDB; 902384at2759; -.
DR PhylomeDB; Q5T1A1; -.
DR TreeFam; TF318254; -.
DR PathwayCommons; Q5T1A1; -.
DR BioGRID-ORCS; 127579; 8 hits in 1066 CRISPR screens.
DR GenomeRNAi; 127579; -.
DR Pharos; Q5T1A1; Tdark.
DR PRO; PR:Q5T1A1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T1A1; protein.
DR Bgee; ENSG00000163354; Expressed in right testis and 89 other tissues.
DR ExpressionAtlas; Q5T1A1; baseline and differential.
DR Genevisible; Q5T1A1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR012858; DC_STAMP-like.
DR Pfam; PF07782; DC_STAMP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..773
FT /note="DC-STAMP domain-containing protein 2"
FT /id="PRO_0000278826"
FT TOPO_DOM 1..26
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..51
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..322
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..415
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 437..499
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 500..520
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 521..773
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 692..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..773
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 284
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 296
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 480
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 625..639
FT /note="LYCLTCFRLLDNTCS -> FICKWHCSSSLVCTP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_023408"
FT VAR_SEQ 640..773
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_023409"
SQ SEQUENCE 773 AA; 86230 MW; 5B48863229DFAB36 CRC64;
MPKVMKDVVH PLGGEEPSMA RAVVRSVGGF TLGLSLATAY GLLELLVEGH SPWGCLVGTL
TLAAFLSLGM GFSRQVRATV LLLLPQAFSR QGRTLLLVAA FGLVLQGPCA NTLRNFTRAS
EAVACGAELA LNQTAEVLQR AKQPLVSALN KIKAIARKTK EVADRVRKFF RSIMDGVKHI
ARALRNVWQW LLHIGDVCNS ELGNPYLKCA RVFDDAKDSC MMVIPQAYHL CYVLMPFKLA
LCGLASLVQV FCVIPKYIQP FLRQTIGTPV IQLLNRVRQE FEFNMTATHH FSVDLNASRS
LSQVAMDLHE AVSMKLHRVR EALALMGFTT PLLLVLLYLQ ALFYRYCYLN WDHYDNIYIT
SRFLRMEAVR STAGLPTVLP LSAHEARRYI PPGSIFLSQW EKFFYILETF NLIRHLLLVL
FLVFLDYAVF WVLDLARHQL QGEIVARSPV LVSLTVEGTG YAGNIYRDLV SAFDVLQQGN
ISILSRRCLL RPSEPDSTGY IVIGVMYGLC FFITLFGSYV SRLRRVICAS YYPSREQERI
SYLYNVLLSR RTNLLAALHR SVRRRAADQG HRSAFLVLAS RCPCLGPFVS HFWLHQAYCL
GCGQPQDEGD MENTVSCSTP GCQGLYCLTC FRLLDNTCSV CASPLSYQGD LDLELDSSDE
EGPQLWLAAA QRKDPEQAWL LQQQLQEVLG RSLSMESTSE SSDLDEEKGP QQRKHGQQPL
PEAHQPVSIL TSPEPHRPPE TSSATKGAPT PASEPSVPLS PPSLPDPSHP PPK
