DCT1A_XENLA
ID DCT1A_XENLA Reviewed; 818 AA.
AC Q8JJ48;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Dapper 1-A;
DE AltName: Full=Dapper1b;
DE Short=XDpr1b;
DE AltName: Full=Functional regulator of dsh in ontogenesis;
DE Short=Frodo;
GN Name=dact1-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH DVL2, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF 810-GLY--VAL-818.
RC TISSUE=Gastrula;
RX PubMed=11941372; DOI=10.1038/ncb784;
RA Gloy J., Hikasa H., Sokol S.Y.;
RT "Frodo interacts with Dishevelled to transduce Wnt signals.";
RL Nat. Cell Biol. 4:351-357(2002).
RN [2]
RP FUNCTION, AND INTERACTION WITH TCF7L1-A.
RX PubMed=15329348; DOI=10.1242/dev.01369;
RA Hikasa H., Sokol S.Y.;
RT "The involvement of Frodo in TCF-dependent signaling and neural tissue
RT development.";
RL Development 131:4725-4734(2004).
RN [3]
RP FUNCTION, AND INTERACTION WITH DBF4.
RX PubMed=15866161; DOI=10.1016/j.devcel.2005.02.012;
RA Brott B.K., Sokol S.Y.;
RT "A vertebrate homolog of the cell cycle regulator Dbf4 is an inhibitor of
RT Wnt signaling required for heart development.";
RL Dev. Cell 8:703-715(2005).
RN [4]
RP FUNCTION, AND INTERACTION WITH CTNND1.
RX PubMed=17084360; DOI=10.1016/j.devcel.2006.09.022;
RA Park J.I., Ji H., Jun S., Gu D., Hikasa H., Li L., Sokol S.Y., McCrea P.D.;
RT "Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct
RT catenin subfamilies promote Wnt signals.";
RL Dev. Cell 11:683-695(2006).
CC -!- FUNCTION: Involved in regulation of intracellular signaling pathways
CC during development. Specifically thought to play a role in canonical
CC and/or non-canonical Wnt signaling pathways through interaction with
CC DSH (Dishevelled) family proteins. Binds to dvl2/dsh and impedes the
CC degradation of beta-catenin (ctnnb1-A and possibly ctnnb1-B), thereby
CC enhancing the transcriptional activation of target genes of the Wnt
CC signaling pathway. Also promotes catenin delta/ctnnd1 stability which
CC in turn promotes zbtb33/kaiso sequestration and thus is involved in the
CC regulation of zbtb33/kaiso-mediated transcriptional repression. May
CC also bind to and directly stimulate the transcriptional activity of
CC tcf7l1-A. Required for eye development and neural patterning.
CC {ECO:0000269|PubMed:11941372, ECO:0000269|PubMed:15329348,
CC ECO:0000269|PubMed:15866161, ECO:0000269|PubMed:17084360}.
CC -!- SUBUNIT: Interacts with dbf4 and tcf7l1-A. Interacts with dvl2/dsh via
CC the C-terminus. {ECO:0000269|PubMed:11941372,
CC ECO:0000269|PubMed:15329348, ECO:0000269|PubMed:15866161,
CC ECO:0000269|PubMed:17084360}.
CC -!- INTERACTION:
CC Q8JJ48; Q8AXM9: ctnnd1; NbExp=6; IntAct=EBI-6259065, EBI-6260685;
CC Q8JJ48; P70062: tcf7l1-a; NbExp=3; IntAct=EBI-6259065, EBI-6259044;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the animal and dorsal marginal regions
CC at late blastula and early gastrula stages. Expressed predominantly in
CC the anterior neural plate at neurulation. Expressed mainly in the
CC ectodermal placodes, including the eye anlagen and the otic vesicle, at
CC later stages of development. {ECO:0000269|PubMed:11941372}.
CC -!- DEVELOPMENTAL STAGE: Expressed bpth maternally and zygotically.
CC {ECO:0000269|PubMed:11941372}.
CC -!- DOMAIN: The C-terminal PDZ-binding motif may mediate interaction with
CC the PDZ domains of DSH (Dishevelled) family proteins.
CC -!- SIMILARITY: Belongs to the dapper family. {ECO:0000305}.
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DR EMBL; AF393622; AAM33467.1; -; mRNA.
DR AlphaFoldDB; Q8JJ48; -.
DR SMR; Q8JJ48; -.
DR IntAct; Q8JJ48; 2.
DR Proteomes; UP000186698; Genome assembly.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0010470; P:regulation of gastrulation; IDA:UniProtKB.
DR GO; GO:0060071; P:Wnt signaling pathway, planar cell polarity pathway; IDA:UniProtKB.
DR InterPro; IPR024848; Dact1.
DR InterPro; IPR024843; Dapper.
DR PANTHER; PTHR15919; PTHR15919; 1.
DR PANTHER; PTHR15919:SF12; PTHR15919:SF12; 1.
DR Pfam; PF15268; Dapper; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Developmental protein; Neurogenesis; Nucleus;
KW Reference proteome; Wnt signaling pathway.
FT CHAIN 1..818
FT /note="Dapper 1-A"
FT /id="PRO_0000191355"
FT REGION 1..337
FT /note="Interaction with tcf7l1-A"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 79..130
FT /evidence="ECO:0000255"
FT MOTIF 815..818
FT /note="PDZ-binding"
FT COMPBIAS 14..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 810..818
FT /note="Missing: Abrogates binding to dvl2."
FT /evidence="ECO:0000269|PubMed:11941372"
SQ SEQUENCE 818 AA; 90360 MW; FBBF0F3B193416A6 CRC64;
MKPIPSPEPP GQLRLTPRRK DKGEAEWERH RTRERLEATL AGLAELDCLR HRQQLLVQNV
LSPGTHGQDA APTGDSPRSD EQKLLEENIS LLKKQLNCLR KRDAGLLSQL HELDKQINDL
KIDSEKTEET DSRPSSGFYE LSDGTSGSLS NSSNSVFSEC LSSCHSSTCF CNPLETSLNL
TDGQAKSAED FLEWLDYRES QHETGTVRCS FSAPHSNSVE VTADVHPKYQ CDLVSKNGND
VYRYPSPLHA VAVQSPMFLI SVMGNIKAEE PEEEIGPNDN DDCIVPELDH LKDEDSFLHQ
SSLCSLPLSS GKKMDGYILS IIHKKAHPVR TNKPRTSVNA DPGKGILRHG SICVKQTVGV
SQSNAVNLKN SKQTCLHSAG MISVDNSTYP SLKPCSKESL SEQLESKRMP SISTYPSCNV
NELQSQNNSR NTVKSVCQGL ARGSVAMTSN VQKENVTPNA PANLPNASSS VCNGSPREST
QNSALLPQEI KVVPPVKRVS LKNTLLSYHE SSSFEERPPL DFKSEGSSSQ SLDEGMLVNA
HYIPAQQHGV KLHKNTKNVK IVKSSTLKHR ADVQYVLENG SQTLKEKSKV VGKKCRFPED
LDTNKKVKKS TPRVKKIVHP HFEPAAVGRN PVAVRSGIKS HGHPKDVVLA KPKHKRSDYR
RWKSSAEISY EEALRRARRR VQREMMGVCA QVPFSHASPY AYIASDSEYS AECESLFHST
VVDTSEDEQS NYTTNCFGDS ESSLSEVEFV GESTTSSDTD ESGGLIWSQF VHTLPMQATA
TAELQTTAKA FIKIKASHNL KKKILRFRSG SLKLMTTV
