ID   DCT2A_XENLA             Reviewed;         403 AA.
AC   Q66J30;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Dynactin subunit 2-A;
GN   Name=dctn2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and
CC       plays a role in prometaphase chromosome alignment and spindle
CC       organization during mitosis. Involved in anchoring microtubules to
CC       centrosomes. May play a role in synapse formation during brain
CC       development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Subunit of dynactin, a multiprotein complex associated with
CC       dynein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynactin subunit 2 family. {ECO:0000305}.
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DR   EMBL; BC081081; AAH81081.1; -; mRNA.
DR   RefSeq; NP_001087686.1; NM_001094217.1.
DR   AlphaFoldDB; Q66J30; -.
DR   MaxQB; Q66J30; -.
DR   DNASU; 447510; -.
DR   GeneID; 447510; -.
DR   KEGG; xla:447510; -.
DR   CTD; 447510; -.
DR   Xenbase; XB-GENE-1000638; dctn2.L.
DR   OrthoDB; 951183at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 447510; Expressed in ovary and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005869; C:dynactin complex; IEA:InterPro.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   InterPro; IPR028133; Dynamitin.
DR   PANTHER; PTHR15346; PTHR15346; 1.
DR   Pfam; PF04912; Dynamitin; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Membrane; Microtubule;
KW   Reference proteome.
FT   CHAIN           1..403
FT                   /note="Dynactin subunit 2-A"
FT                   /id="PRO_0000288769"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          99..132
FT                   /evidence="ECO:0000255"
FT   COILED          381..401
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   403 AA;  44738 MW;  86BE8CEE54325EF3 CRC64;
     MADPKYADLP GIARNEPDVY ETSDLPEDDQ AEFDAEELTS TSVEHIIVNP NAAYDKFKDK
     KVGTRSLDFS DRITKSKRTG YESGEYEILG EGIGMKETPQ QKYQRLLHEV QELTQEVEKT
     QSTVKESAAE EKLTPVALAK QVASLKQQLV STHLEKLLGP DAAINLTDPD GALAKRLLTQ
     LDAAKTRKNP EGKSPAKGPG PDTENLVTYE LHCRPEQNKF SQAAKMAELE KRLGELEVAV
     RCDQDTQNPL TVGLQGSCLM DTVEILQAKV NLLDVASLDQ VEARLQSVLG KMNEIAKHKA
     AIEDADTESK VHQLYETVQK WDSMSGTLPQ VVQRLLTLKQ LHEQAMQFGQ LLTHLDTTQQ
     MIANSLKDNT NALAMVQKAM KENLATVEDN FSNIDGRIKK LSK