DCT2B_XENLA
ID DCT2B_XENLA Reviewed; 403 AA.
AC Q6IRB3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Dynactin subunit 2-B;
GN Name=dctn2-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and
CC plays a role in prometaphase chromosome alignment and spindle
CC organization during mitosis. Involved in anchoring microtubules to
CC centrosomes. May play a role in synapse formation during brain
CC development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Subunit of dynactin, a multiprotein complex associated with
CC dynein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}. Membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the dynactin subunit 2 family. {ECO:0000305}.
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DR EMBL; BC070987; AAH70987.1; -; mRNA.
DR RefSeq; NP_001080607.1; NM_001087138.1.
DR AlphaFoldDB; Q6IRB3; -.
DR DNASU; 380299; -.
DR GeneID; 380299; -.
DR KEGG; xla:380299; -.
DR CTD; 380299; -.
DR Xenbase; XB-GENE-6256553; dctn2.S.
DR OrthoDB; 951183at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 380299; Expressed in blastula and 19 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005869; C:dynactin complex; IEA:InterPro.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR InterPro; IPR028133; Dynamitin.
DR PANTHER; PTHR15346; PTHR15346; 1.
DR Pfam; PF04912; Dynamitin; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Membrane; Microtubule;
KW Reference proteome.
FT CHAIN 1..403
FT /note="Dynactin subunit 2-B"
FT /id="PRO_0000288770"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 99..132
FT /evidence="ECO:0000255"
FT COILED 381..401
FT /evidence="ECO:0000255"
SQ SEQUENCE 403 AA; 44829 MW; 9FD158C7C7983062 CRC64;
MADPKYADLP GIARNEPDLY ETSDLPEDDQ AEFDAEELTS TSVEHIIVNP NAAYDKFKDK
KVGTRCLDFS DRITKSKRTG YESGEYEILG EGLGIKETPQ QKYQRLLHEV QELTQEVEKT
QSTLKESATE EKLTPVALAK QVAALKQQLV STHLEKLLGP DAAINLTDPD GALAKRLLTQ
LDAAKTRKDP EGKSSAKGPG PDNENLVTYE LHCRPEQNKF SQAAKMAELE KRLGELEAAV
RCDQDTQNPL TVGLQGSCLM DTVEILQAKV NLLDVASLDQ VEARLQSVLG KMNEIAKHKA
TIEDADTESK VHQLYETVQK WDSMSITLPQ VVQRLLTLKQ LHEQAMQFGQ LLTHLDTTQQ
MISNSLKDNT NALAMVQKAM KENLATVEDN FSSIDGRIKK LSK