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DCT2B_XENLA
ID   DCT2B_XENLA             Reviewed;         403 AA.
AC   Q6IRB3;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Dynactin subunit 2-B;
GN   Name=dctn2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and
CC       plays a role in prometaphase chromosome alignment and spindle
CC       organization during mitosis. Involved in anchoring microtubules to
CC       centrosomes. May play a role in synapse formation during brain
CC       development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Subunit of dynactin, a multiprotein complex associated with
CC       dynein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynactin subunit 2 family. {ECO:0000305}.
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DR   EMBL; BC070987; AAH70987.1; -; mRNA.
DR   RefSeq; NP_001080607.1; NM_001087138.1.
DR   AlphaFoldDB; Q6IRB3; -.
DR   DNASU; 380299; -.
DR   GeneID; 380299; -.
DR   KEGG; xla:380299; -.
DR   CTD; 380299; -.
DR   Xenbase; XB-GENE-6256553; dctn2.S.
DR   OrthoDB; 951183at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 380299; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005869; C:dynactin complex; IEA:InterPro.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   InterPro; IPR028133; Dynamitin.
DR   PANTHER; PTHR15346; PTHR15346; 1.
DR   Pfam; PF04912; Dynamitin; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Dynein; Membrane; Microtubule;
KW   Reference proteome.
FT   CHAIN           1..403
FT                   /note="Dynactin subunit 2-B"
FT                   /id="PRO_0000288770"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          99..132
FT                   /evidence="ECO:0000255"
FT   COILED          381..401
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   403 AA;  44829 MW;  9FD158C7C7983062 CRC64;
     MADPKYADLP GIARNEPDLY ETSDLPEDDQ AEFDAEELTS TSVEHIIVNP NAAYDKFKDK
     KVGTRCLDFS DRITKSKRTG YESGEYEILG EGLGIKETPQ QKYQRLLHEV QELTQEVEKT
     QSTLKESATE EKLTPVALAK QVAALKQQLV STHLEKLLGP DAAINLTDPD GALAKRLLTQ
     LDAAKTRKDP EGKSSAKGPG PDNENLVTYE LHCRPEQNKF SQAAKMAELE KRLGELEAAV
     RCDQDTQNPL TVGLQGSCLM DTVEILQAKV NLLDVASLDQ VEARLQSVLG KMNEIAKHKA
     TIEDADTESK VHQLYETVQK WDSMSITLPQ VVQRLLTLKQ LHEQAMQFGQ LLTHLDTTQQ
     MISNSLKDNT NALAMVQKAM KENLATVEDN FSSIDGRIKK LSK
 
 
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