ID   DCT6_CAEEL              Reviewed;         923 AA.
AC   Q09313; Q2PJB0; Q2PJB1;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Protein dct-6;
DE   AltName: Full=Daf-16/foxo controlled, germline tumor-affecting protein 6;
GN   Name=dct-6; ORFNames=F25B5.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION.
RX   PubMed=17934462; DOI=10.1038/ng.2007.1;
RA   Pinkston-Gosse J., Kenyon C.;
RT   "DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis
RT   elegans.";
RL   Nat. Genet. 39:1403-1409(2007).
CC   -!- FUNCTION: May have a role in tumor suppression.
CC       {ECO:0000269|PubMed:17934462}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=b;
CC         IsoId=Q09313-1; Sequence=Displayed;
CC       Name=a;
CC         IsoId=Q09313-2; Sequence=VSP_018518;
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DR   EMBL; FO081045; CCD68771.1; -; Genomic_DNA.
DR   EMBL; FO081045; CCD68772.1; -; Genomic_DNA.
DR   PIR; T16150; T16150.
DR   RefSeq; NP_001033357.2; NM_001038268.2. [Q09313-2]
DR   RefSeq; NP_001033358.2; NM_001038269.3. [Q09313-1]
DR   AlphaFoldDB; Q09313; -.
DR   BioGRID; 41067; 3.
DR   STRING; 6239.F25B5.1b; -.
DR   EPD; Q09313; -.
DR   PaxDb; Q09313; -.
DR   PeptideAtlas; Q09313; -.
DR   EnsemblMetazoa; F25B5.1a.1; F25B5.1a.1; WBGene00017773. [Q09313-2]
DR   EnsemblMetazoa; F25B5.1b.1; F25B5.1b.1; WBGene00017773. [Q09313-1]
DR   GeneID; 175846; -.
DR   KEGG; cel:CELE_F25B5.1; -.
DR   CTD; 175846; -.
DR   WormBase; F25B5.1a; CE39493; WBGene00017773; dct-6. [Q09313-2]
DR   WormBase; F25B5.1b; CE39494; WBGene00017773; dct-6. [Q09313-1]
DR   eggNOG; ENOG502TGY7; Eukaryota.
DR   HOGENOM; CLU_318130_0_0_1; -.
DR   InParanoid; Q09313; -.
DR   OMA; AYYDGFV; -.
DR   OrthoDB; 135499at2759; -.
DR   PRO; PR:Q09313; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00017773; Expressed in material anatomical entity and 4 other tissues.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   4: Predicted;
KW   Alternative splicing; Coiled coil; Reference proteome.
FT   CHAIN           1..923
FT                   /note="Protein dct-6"
FT                   /id="PRO_0000065313"
FT   COILED          312..347
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         497..504
FT                   /note="Missing (in isoform a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_018518"
SQ   SEQUENCE   923 AA;  104340 MW;  3A8619BDE150BDBC CRC64;
     MIESTTSHQD FQQRSMTGYA LEHPSYRIRG ALFRHQDDGR LLSGCGGDIE VIHALELERS
     QHTCLPVRVT NVVVFGSNDV VRLIQPIEGT EDVIVNGDYH VSIVQSVELF ESSTVSKSRI
     LKLPGKIIAV NAEKHSNTEL LLVFLLETGI FHYSFCAHTS THFQCIQAFR CNRPITSGLL
     WRDSGLLHVA YYDGFVRVGV VHEQYDDMLL VKRVAVNRNN LSVLLDVVFE EIGRIQKFED
     TEKQRREDML TTSKSLSDKL VAEEEVVEGD TTNDDFAKLK IEFKNQSIRC ERVSQRLTSL
     RKLITIIKSA LDMNDQIEQM ISLLVDELSE LEKLEQLCKE VERTGNQNLI GKSWIAVEEK
     QMVVEELIAK VNSDQIKKHS DVWEQKIDQI IDQLNGCSEA AKDMRLIISQ NIFEHRGDKK
     DVFTHFVLDA QSRDITLYCL SGLTTMAIYP RKGKRVASIS LDASFATCLT AACAMKSAEG
     VYVADQNNVF PTYFYRNRPK AGKGEKRYLD AGNQLQLPTF DSISSILVEP HQMILGSVTG
     GLLHLSFDFA SNYEHFVVAS SILAHPISSG SVNCIKLLAT GESLLALHCT DTEIVVSEKD
     QERWHRVTHH TGGAHAIAVT PFSVDERGAF AVVASDTFVR LKVLQYAEES LIGLHDLGES
     RAEDENGHPI EVLNVSLDPS MQYRQLPCKL RYAVGFADKA IRTYVALLTG QHDFNVQEKF
     IAQIEPLFNV QNMICFHGRP MGCYVSCAKT LQIWNDLDRH QQKKLKSERM QLLKLSSSVT
     SMERAEGYLL LGFADDRLSI YEEKGNGAVD LVGTVDDWHK GLNDRIVMSL RTRASKTSCG
     TRLFIHSLTA HHIVIHTVLV TASKIEQHDF IVAHEHSMSQ PIGFEFVSYK YFEFLVYGRG
     ISNEKLSIED RKRMDNFRDF EFN