DCTA1_PSEA7
ID DCTA1_PSEA7 Reviewed; 444 AA.
AC A6UXQ5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=C4-dicarboxylate transport protein 1 {ECO:0000255|HAMAP-Rule:MF_01300};
GN Name=dctA1 {ECO:0000255|HAMAP-Rule:MF_01300}; OrderedLocusNames=PSPA7_0194;
OS Pseudomonas aeruginosa (strain PA7).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=381754;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PA7;
RA Dodson R.J., Harkins D., Paulsen I.T.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC succinate, fumarate, and malate from the periplasm across the membrane.
CC {ECO:0000255|HAMAP-Rule:MF_01300}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01300}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01300}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000255|HAMAP-Rule:MF_01300}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000744; ABR81852.1; -; Genomic_DNA.
DR AlphaFoldDB; A6UXQ5; -.
DR SMR; A6UXQ5; -.
DR EnsemblBacteria; ABR81852; ABR81852; PSPA7_0194.
DR KEGG; pap:PSPA7_0194; -.
DR HOGENOM; CLU_019375_7_0_6; -.
DR OMA; GHGMNVD; -.
DR Proteomes; UP000001582; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3860.10; -; 1.
DR HAMAP; MF_01300; C4_dicarb_transport; 1.
DR InterPro; IPR023954; C4_dicarb_transport.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865; PTHR42865; 1.
DR Pfam; PF00375; SDF; 1.
DR SUPFAM; SSF118215; SSF118215; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..444
FT /note="C4-dicarboxylate transport protein 1"
FT /id="PRO_0000321990"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
SQ SEQUENCE 444 AA; 46896 MW; 02C4FC50534B8B88 CRC64;
MFIKRCSRSI FLQVVIGLVI GVLCGVGIPD LAVQMKPLGD GFIKLIKMLI ALIVFCVVVN
GISGAGDLKK VGRIGLKSVI YFEILTTIAL VLGLVVAYSL GLGSGANIHL NELPAGDIAL
YTGRTQEIHG PVAFLMGLIP TSVFSAFAEN DILQVLLFSV LFGSALNLVG EQASGVARLI
NEFSHIVFRI MGMIVRLAPL GVFGAVAFTT ARYGVDSLSH LGALVLVFYA TCLVFVMAVL
GSVLRLSGVR MLPFLRYFRE ELLIVMGTAS SDAVLPQVMR KLEHMGIRSS TVGLVIPTGY
SFNLDGFSIY LTLAVVFIAH VTGTPLAMTD LLTILLVSLV TSKGAHGIPG SALVILAATL
TAVPAIPVAG LVLVLSVDWF MGIGRALTNL IGNCVATVTI ARWENDIDLP RAQAILDGRL
EAPTRTGGEP LERGVVAGEG KLQG
