ID   DCTA1_PSEAB             Reviewed;         449 AA.
AC   Q02UV9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=C4-dicarboxylate transport protein 1 {ECO:0000255|HAMAP-Rule:MF_01300};
GN   Name=dctA1 {ECO:0000255|HAMAP-Rule:MF_01300}; OrderedLocusNames=PA14_01460;
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14;
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G.,
RA   Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01300}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01300}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01300}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000255|HAMAP-Rule:MF_01300}.
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DR   EMBL; CP000438; ABJ15076.1; -; Genomic_DNA.
DR   RefSeq; WP_003137006.1; NZ_CP034244.1.
DR   AlphaFoldDB; Q02UV9; -.
DR   SMR; Q02UV9; -.
DR   EnsemblBacteria; ABJ15076; ABJ15076; PA14_01460.
DR   KEGG; pau:PA14_01460; -.
DR   HOGENOM; CLU_019375_7_0_6; -.
DR   OMA; AVDWFMG; -.
DR   BioCyc; PAER208963:G1G74-124-MON; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..449
FT                   /note="C4-dicarboxylate transport protein 1"
FT                   /id="PRO_0000321992"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        385..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
SQ   SEQUENCE   449 AA;  47414 MW;  9B6C06DEC21939BD CRC64;
     METPAMFIKR CSRSIFLQVV IGLVIGVICG VGIPDLAVQM KPLGDGFIKL IKMLIALIVF
     CVVVNGISGA GDLKKVGRIG LKSVIYFEIL TTIALVLGLV VAYSLGLGSG ANIHLNELPA
     GDVALYTGRT QEIHGPVAFL MGLIPTSVFS AFAENDILQV LLFSVLFGSA LNLVGEQASG
     VARLINEFSH IVFRIMGMIV RLAPLGVFGA VAFTTARYGV DSLSHLGALV LVFYATCLVF
     VMAVLGSVLR LSGVRMLPFL RYFREELMIV MGTASSDAVL PQVMRKLEHM GIRSSTVGLV
     IPTGYSFNLD GFSIYLTLAV VFIAHVTGTP LAMTDLVTIL LVSLVTSKGA HGIPGSALVI
     LAATLTAVPA IPVAGLVLVL SVDWFMGIGR ALTNLIGNCV ATVTIARWEN DIDMPRAQAI
     LDGRLEAPAK ADGEPLKRSA VAGEGKLHG