DCTA1_PSEAE
ID DCTA1_PSEAE Reviewed; 449 AA.
AC Q9I713;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=C4-dicarboxylate transport protein 1;
GN Name=dctA1; OrderedLocusNames=PA0119;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC succinate, fumarate, and malate from the periplasm across the membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR EMBL; AE004091; AAG03509.1; -; Genomic_DNA.
DR PIR; H83629; H83629.
DR RefSeq; NP_248809.1; NC_002516.2.
DR RefSeq; WP_003142411.1; NZ_QZGE01000015.1.
DR AlphaFoldDB; Q9I713; -.
DR SMR; Q9I713; -.
DR STRING; 287.DR97_3076; -.
DR PaxDb; Q9I713; -.
DR PRIDE; Q9I713; -.
DR EnsemblBacteria; AAG03509; AAG03509; PA0119.
DR GeneID; 877578; -.
DR KEGG; pae:PA0119; -.
DR PATRIC; fig|208964.12.peg.124; -.
DR PseudoCAP; PA0119; -.
DR HOGENOM; CLU_019375_7_0_6; -.
DR InParanoid; Q9I713; -.
DR OMA; AVDWFMG; -.
DR PhylomeDB; Q9I713; -.
DR BioCyc; PAER208964:G1FZ6-121-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015138; F:fumarate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015366; F:malate:proton symporter activity; IBA:GO_Central.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0070778; P:L-aspartate transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.3860.10; -; 1.
DR HAMAP; MF_01300; C4_dicarb_transport; 1.
DR InterPro; IPR023954; C4_dicarb_transport.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865; PTHR42865; 1.
DR Pfam; PF00375; SDF; 1.
DR SUPFAM; SSF118215; SSF118215; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..449
FT /note="C4-dicarboxylate transport protein 1"
FT /id="PRO_0000202097"
FT TRANSMEM 16..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..380
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 449 AA; 47410 MW; C2C0D105AEAF3317 CRC64;
METPAMFIKR CSRSIFLQVV IGLVIGVICG VGIPDLAVQM KPLGDGFIKL IKMLIALIVF
CVVVNGISGA GDLKKVGRIG LKSVIYFEIL TTIALVLGLV VAYSLGLGSG ANIHLNELPA
GDVALYTGRT QEIHGPVAFL MGLIPTSVFS AFAENDILQV LLFSVLFGSA LNLVGEQASG
VARLINEFSH IVFRIMGMIV RLAPLGVFGA VAFTTARYGV DSLSHLGALV LVFYATCLVF
VMAVLGSVLR LSGVRMLPFL RYFREELLIV MGTASSDAVL PQVMRKLEHM GIRSSTVGLV
IPTGYSFNLD GFSIYLTLAV VFIAHVTGTP LAMTDLITIL LVSLVTSKGA HGIPGSALVI
LAATLTAVPA IPVAGLVLVL SVDWFMGIGR ALTNLIGNCV ATVTIARWEN DIDMPRAQAI
LDGRLEAPAK ADGEPLKRSA VAGEGKLHG
