ID   DCTA1_RALSO             Reviewed;         428 AA.
AC   Q8Y2K5;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   05-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=C4-dicarboxylate transport protein 1;
GN   Name=dctA1; OrderedLocusNames=RSc0330; ORFNames=RS03297;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA   Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA   Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA   Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA   Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the membrane.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR   EMBL; AL646052; CAD13858.1; -; Genomic_DNA.
DR   RefSeq; WP_011000294.1; NC_003295.1.
DR   AlphaFoldDB; Q8Y2K5; -.
DR   SMR; Q8Y2K5; -.
DR   STRING; 267608.RSc0330; -.
DR   EnsemblBacteria; CAD13858; CAD13858; RSc0330.
DR   GeneID; 60499836; -.
DR   KEGG; rso:RSc0330; -.
DR   eggNOG; COG1301; Bacteria.
DR   HOGENOM; CLU_019375_7_0_4; -.
DR   OMA; YLYIAVI; -.
DR   Proteomes; UP000001436; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..428
FT                   /note="C4-dicarboxylate transport protein 1"
FT                   /id="PRO_0000202102"
FT   TRANSMEM        5..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   428 AA;  45432 MW;  89E09E112C8BE4F2 CRC64;
     MKKPFYKILY VQVLAAIVIG VLLGHFEPKL AVNMKPLGDG FIQLIKMVIG PIIFCTVVSG
     IAGMRDMKKV GRVGGKALLY FEVVSTFALV IGLVAGHIFN PGSGFNVDVN SIDAKAVAQY
     AAKAQSSSTV DFLLNIIPST VVDAFAKGDI LQILLIALLF GGALSAMGER AQMVTDFIDQ
     IAHVFFRIVH VITRVAPIGA FGAMAFTIGK YGVVSLVPLL KLIGTFYLTA IIFVVVVLGI
     IARLTGFSIF RFVAYIKEEL LIVLGTSSSE SALPHLMEKM EKLGCSKSVV GLVVPTGYSF
     NLDGTNIYMT MAVIFISQAL NIELTLTQQL TILAVAMLTS KGASGITGAG FITLAATLAV
     VPTIPVAGMV LILGIDRFMS ECRALTNITG NGVACVVISA WERELDRTKL ARVMSGDRGE
     TVSATPAA