ID   DCTA2_BRASO             Reviewed;         445 AA.
AC   A4YTR6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=C4-dicarboxylate transport protein 2 {ECO:0000255|HAMAP-Rule:MF_01300};
GN   Name=dctA2 {ECO:0000255|HAMAP-Rule:MF_01300}; OrderedLocusNames=BRADO3510;
OS   Bradyrhizobium sp. (strain ORS 278).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium; unclassified Bradyrhizobium.
OX   NCBI_TaxID=114615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ORS 278;
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA   Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E.,
RA   Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA   Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01300}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01300}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01300}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000255|HAMAP-Rule:MF_01300}.
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DR   EMBL; CU234118; CAL77292.1; -; Genomic_DNA.
DR   RefSeq; WP_011926438.1; NC_009445.1.
DR   AlphaFoldDB; A4YTR6; -.
DR   SMR; A4YTR6; -.
DR   STRING; 114615.BRADO3510; -.
DR   EnsemblBacteria; CAL77292; CAL77292; BRADO3510.
DR   KEGG; bra:BRADO3510; -.
DR   eggNOG; COG1301; Bacteria.
DR   HOGENOM; CLU_019375_7_0_5; -.
DR   OMA; AQIYGIP; -.
DR   OrthoDB; 781228at2; -.
DR   BioCyc; BSP114615:BRADO_RS16380-MON; -.
DR   Proteomes; UP000001994; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..445
FT                   /note="C4-dicarboxylate transport protein 2"
FT                   /id="PRO_0000321974"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
SQ   SEQUENCE   445 AA;  47025 MW;  14C2724E9412855C CRC64;
     MAAATDIGTR DVPSQTGKKP WYSILYVQVL IAILIGIVVG WLFPNLATND WIKALGDGFI
     KLIKMVIAPI IFCTVVSGIA HIQNASKVGR VGVKALVYFE IVSTFALLLG LIVGNLAPIG
     HGLAAKPDAA AVANYVKQAE AQKSVDFVLN IIPDSVVGAL ARGDILQVLL FAILFGFALM
     ALGERGHRLR DIIDDTAHAV FGVIAIVMKA APVGAFGAMA FTIGKYGPAA LGNLIGLIAL
     FYITAGLFVV IVLGLIARFI GFSIFKFVAY IKDELLIVLG TSSSESALPQ LMEKLERLGC
     SKPVVGLVVP TGYSFNLDGT NIYMTLATLF ISQALGVDLS FSQQVTILIV AMLTSKGASG
     VTGAGFITLA ATLSVVNPAL VPGMAIVFSI DKFMSEVRAL TNITGNGIAA VFVSWWEGEL
     DHDLLQRRLN QQIDPSDVET AVTTG