ID   DCTA2_POLNA             Reviewed;         448 AA.
AC   A1VTR6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=C4-dicarboxylate transport protein 2 {ECO:0000255|HAMAP-Rule:MF_01300};
GN   Name=dctA2 {ECO:0000255|HAMAP-Rule:MF_01300}; OrderedLocusNames=Pnap_3748;
OS   Polaromonas naphthalenivorans (strain CJ2).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Polaromonas.
OX   NCBI_TaxID=365044;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CJ2;
RX   PubMed=19453698; DOI=10.1111/j.1462-2920.2009.01947.x;
RA   Yagi J.M., Sims D., Brettin T., Bruce D., Madsen E.L.;
RT   "The genome of Polaromonas naphthalenivorans strain CJ2, isolated from coal
RT   tar-contaminated sediment, reveals physiological and metabolic versatility
RT   and evolution through extensive horizontal gene transfer.";
RL   Environ. Microbiol. 11:2253-2270(2009).
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01300}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01300}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01300}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000255|HAMAP-Rule:MF_01300}.
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DR   EMBL; CP000529; ABM39044.1; -; Genomic_DNA.
DR   RefSeq; WP_011803110.1; NC_008781.1.
DR   AlphaFoldDB; A1VTR6; -.
DR   SMR; A1VTR6; -.
DR   STRING; 365044.Pnap_3748; -.
DR   EnsemblBacteria; ABM39044; ABM39044; Pnap_3748.
DR   KEGG; pna:Pnap_3748; -.
DR   eggNOG; COG1301; Bacteria.
DR   HOGENOM; CLU_019375_7_0_4; -.
DR   OMA; YLYIAVI; -.
DR   OrthoDB; 781228at2; -.
DR   Proteomes; UP000000644; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..448
FT                   /note="C4-dicarboxylate transport protein 2"
FT                   /id="PRO_5000211347"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
SQ   SEQUENCE   448 AA;  47615 MW;  80D42FFEB1D22402 CRC64;
     MSKTNARKPI YKSLYVQVLA AVTIGVLLGH FSPELGAQMK PLGDGFIKLI KMIIAPIIFC
     TVVIGIAGME DMKKVGKTGG LALLYFEVMS TLALVIGLIV VNVLQPGSGM HIDPASLDTK
     SIAAYTAPGK MQGTVDFLLN VIPTSVVDAF AKGEILQVLL FSVLFGFALH RFGGRGTMVF
     DFIEKFSHVL FDIVGIIMKV APIGAFGAMA FTIGKYGLGS LFSLGKLMGA FYLTCLIFVF
     VVLGIVSRLH GFSVFKFVRY IKEELLIVLG TSSSESVLPR MMEKLENLGA RKSVVGLVIP
     TGYSFNLDGT SIYLTMAAVF IAQATDTPMS LTQQITLLAV LMLTSKGAAG ITGSGFIVLA
     ATLSAVGGVP VAGLALILGI DRFMSEARAL TNLVGNGVAT LVVAKWTGDL DMQRLHQGLD
     QPSLQESQEP EVILDQQVAH MAVAKSHG