ID   DCTA2_PSEA7             Reviewed;         436 AA.
AC   A6V915;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=C4-dicarboxylate transport protein 2 {ECO:0000255|HAMAP-Rule:MF_01300};
GN   Name=dctA2 {ECO:0000255|HAMAP-Rule:MF_01300}; OrderedLocusNames=PSPA7_4196;
OS   Pseudomonas aeruginosa (strain PA7).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=381754;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA7;
RA   Dodson R.J., Harkins D., Paulsen I.T.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01300}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01300}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01300}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000255|HAMAP-Rule:MF_01300}.
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DR   EMBL; CP000744; ABR86738.1; -; Genomic_DNA.
DR   RefSeq; WP_012076662.1; NC_009656.1.
DR   AlphaFoldDB; A6V915; -.
DR   SMR; A6V915; -.
DR   PRIDE; A6V915; -.
DR   EnsemblBacteria; ABR86738; ABR86738; PSPA7_4196.
DR   KEGG; pap:PSPA7_4196; -.
DR   HOGENOM; CLU_019375_7_0_6; -.
DR   OMA; YLYIAVI; -.
DR   OrthoDB; 781228at2; -.
DR   Proteomes; UP000001582; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..436
FT                   /note="C4-dicarboxylate transport protein 2"
FT                   /id="PRO_0000321991"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   REGION          414..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   436 AA;  46022 MW;  926EA1B326D31FFD CRC64;
     MTKQPFYKSL YVQVLVAIAI GIALGHWYPE TAVAMKPFGD GFVKLIKMAI APIIFCTVVT
     GIAGMQSMKS VGKTGGMALL YFEIVSTVAL IIGLVVVNLV QPGAGMHVDP NTLDTSKIAA
     YAAAGEKQST VDFLMNVIPG TVVGAFANGD ILQVLFFSVL FGYALHRLGS YGKPVFEFIE
     RVSHVMFNII NVIMKVAPIG AFGAMAFTIG AYGVGSLVQL GQLMLCFYIT CLLFVLIVLG
     GIARAHGFSI LRFIRYIREE LLIVLGTSSS ESALPRMIDK MEKLGCNKSV VGLVIPTGYS
     FNLDGTSIYL TMAAVFIAQA TDTPMDITHQ ITLLLVLLIA SKGAAGVTGS GFIVLAATLS
     AVGHLPVAGL ALILGIDRFM SEARALTNLV GNGVATVVVS KWCKQLDEGT LQRELAGEGN
     ASSPASDIPV GGREAV