ID   DCTA2_RALSO             Reviewed;         446 AA.
AC   Q8XUB6;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   05-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=C4-dicarboxylate transport protein 2;
GN   Name=dctA2; OrderedLocusNames=RSc3275; ORFNames=RS02504;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA   Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA   Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA   Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA   Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the membrane.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR   EMBL; AL646052; CAD17063.1; -; Genomic_DNA.
DR   RefSeq; WP_011003160.1; NC_003295.1.
DR   AlphaFoldDB; Q8XUB6; -.
DR   SMR; Q8XUB6; -.
DR   STRING; 267608.RSc3275; -.
DR   EnsemblBacteria; CAD17063; CAD17063; RSc3275.
DR   GeneID; 60502787; -.
DR   KEGG; rso:RSc3275; -.
DR   PATRIC; fig|267608.8.peg.3324; -.
DR   eggNOG; COG1301; Bacteria.
DR   HOGENOM; CLU_019375_7_0_4; -.
DR   OMA; GHGMNVD; -.
DR   Proteomes; UP000001436; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..446
FT                   /note="C4-dicarboxylate transport protein 2"
FT                   /id="PRO_0000202103"
FT   TRANSMEM        7..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   446 AA;  46571 MW;  A7A89F2580D03E30 CRC64;
     MQRFTRPLFG QVLIALALGI ALGIWAPDFA QHLKPLGDGF LKLIKMLIAP IVFSVVVVGI
     CGAGELKKVG RVGGKAVIYF EVVTTIALAL GIALAYAFGP GHGMNVDPKT LDASAMSSYM
     ATAKQVESSG VAEFLLKLIP DTFVSGFMKG DILQVLLVSI LFGCALSLLG ERTKPLVGLI
     DQLSHVLFRM MAVVIRLAPL GVLGAVAFTV GKYGAGSLKQ LGFLVLLFYA AVAVFVVVVL
     GGILRLAGFS IFKLIRFLRA ELLVVLGTAS SDAVLPSVMN KLEKMGIKRS VVGLVIPTGY
     SFNLDAFSIY LTLAAVFIAQ ATNTPLALSD LLLILGVALI TSKGAHGIPG SAIVILAATL
     SVIPAIPAIG LVLVLSVDWF IGIARALGNL LGNCVATVVI AAWEKDIDRA RANAVLDGKL
     DIIEEGEAAA RGHGIQVPSA STLPHA