ID   DCTA2_RHILO             Reviewed;         442 AA.
AC   Q986R8;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=C4-dicarboxylate transport protein 2;
GN   Name=dctA2; OrderedLocusNames=mll7237;
OS   Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
OS   (Mesorhizobium loti (strain MAFF 303099)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 29417 / CECT 9101 / MAFF 303099;
RX   PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA   Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y.,
RA   Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y.,
RA   Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT   Mesorhizobium loti.";
RL   DNA Res. 7:331-338(2000).
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the membrane.
CC       This transport system plays an important role in the energy supply of
CC       rhizobium-legume symbionts (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR   EMBL; BA000012; BAB53385.1; -; Genomic_DNA.
DR   RefSeq; WP_010914692.1; NC_002678.2.
DR   AlphaFoldDB; Q986R8; -.
DR   SMR; Q986R8; -.
DR   STRING; 266835.14026789; -.
DR   EnsemblBacteria; BAB53385; BAB53385; BAB53385.
DR   KEGG; mlo:mll7237; -.
DR   PATRIC; fig|266835.9.peg.5780; -.
DR   eggNOG; COG1301; Bacteria.
DR   HOGENOM; CLU_019375_7_0_5; -.
DR   OMA; YLYIAVI; -.
DR   OrthoDB; 781228at2; -.
DR   Proteomes; UP000000552; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..442
FT                   /note="C4-dicarboxylate transport protein 2"
FT                   /id="PRO_0000202108"
FT   TRANSMEM        20..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        342..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   442 AA;  46095 MW;  75704505629B1D82 CRC64;
     MHIADQSGAA AAQRKPLYAQ LYVQVLVAIT VGILLGHYYP SIGESMKPLG DAFIKLVKMI
     IAPVIFLTVA TGIAGMSDLQ KVGRVAGKAM LYFLTFSTLA LIIGLVVANV VQPGAGFNID
     PATLDASTVN TYAAKAHDQS VTGFLMNIIP GTIVGAFADG DILQVLFFSV LFGIALALVG
     DKGAPVLNFL QALMAPMFKL VSVLMKAAPI GAFGAMAFTI GKYGIGSVIN LAMLVGTFYA
     TSLLFVFVVL GAVCRYNGFS ILSLLRYIKE ELLLVLGTSS SEAALPSLME KMEKAGAKRS
     VVGLVIPTGY SFNLDGTNIY MTLAALFIAQ ATNIHLSMGD QILLLLVAML SSKGAAGITG
     AGFITLAATL SVVPSVPVAG MALILGVDRF MSECRALTNF IGNAVATLVV ARWEGELDEA
     KLARALAGTA DDSLPADIVP AE