ID   DCTA3_RALSO             Reviewed;         447 AA.
AC   Q8XR66;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   05-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=C4-dicarboxylate transport protein 3;
GN   Name=dctA3; OrderedLocusNames=RSp0995; ORFNames=RS02327;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OG   Plasmid megaplasmid Rsp.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA   Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA   Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA   Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA   Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the membrane.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR   EMBL; AL646053; CAD18146.1; -; Genomic_DNA.
DR   RefSeq; WP_011004285.1; NC_003296.1.
DR   AlphaFoldDB; Q8XR66; -.
DR   SMR; Q8XR66; -.
DR   STRING; 267608.RSp0995; -.
DR   EnsemblBacteria; CAD18146; CAD18146; RSp0995.
DR   GeneID; 60503907; -.
DR   KEGG; rso:RSp0995; -.
DR   PATRIC; fig|267608.8.peg.4476; -.
DR   eggNOG; COG1301; Bacteria.
DR   HOGENOM; CLU_019375_7_0_4; -.
DR   OMA; AVDWFMG; -.
DR   Proteomes; UP000001436; Plasmid megaplasmid Rsp.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Plasmid; Reference proteome;
KW   Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..447
FT                   /note="C4-dicarboxylate transport protein 3"
FT                   /id="PRO_0000202104"
FT   TRANSMEM        5..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   447 AA;  46991 MW;  7653E46F3D01DD0A CRC64;
     MIRKTLGKLY VQVLIGVAAG IVQGVAAPNL GSDLKPLGDV FIKLIKMVFA PIIFATVTLG
     IARMENMKEL GRVGVRALVY FEVLSTFALA LGLIVVNLVQ PGQGMNVDAA HLDTKAIASY
     THAAARPQTF VDFLLSLVPS SIIDALARND ILQILVFATL FGIALSRMGT RARPVVDFLD
     VFTQGVFSIV GMIMRLAPIA AFGAMAFTVG KYGLGSIAAL GKLMATMYLT CVLFVAIVLG
     GVARLAGFSL WKFLRYIRDE IFTVLGTSSS ESVVPQLMRK LESAGVSKPV VGLVVPSGLT
     FNPDGQCIYY TMAAIFVAQA TNTPLTLTDQ LVVLGVLLLT SKGSAGVTGS GFITLAATLA
     SLGKIPVAGM VLLLGIDRFM SEARAITNTI GNAVGTLAIA RWVGAVDRER LQAALDGVPE
     AAQTPPQAVH VHAPVAHVEA AHPPLAH