ID   DCTA4_BRADU             Reviewed;         442 AA.
AC   Q89EA0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=C4-dicarboxylate transport protein 4 {ECO:0000255|HAMAP-Rule:MF_01300};
GN   Name=dctA4 {ECO:0000255|HAMAP-Rule:MF_01300}; OrderedLocusNames=blr7187;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01300}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01300}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01300}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000255|HAMAP-Rule:MF_01300}.
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DR   EMBL; BA000040; BAC52452.1; -; Genomic_DNA.
DR   RefSeq; NP_773827.1; NC_004463.1.
DR   RefSeq; WP_011089922.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q89EA0; -.
DR   SMR; Q89EA0; -.
DR   STRING; 224911.27355469; -.
DR   EnsemblBacteria; BAC52452; BAC52452; BAC52452.
DR   GeneID; 64026946; -.
DR   KEGG; bja:blr7187; -.
DR   PATRIC; fig|224911.44.peg.7255; -.
DR   eggNOG; COG1301; Bacteria.
DR   HOGENOM; CLU_019375_7_0_5; -.
DR   InParanoid; Q89EA0; -.
DR   OMA; RNPYTFI; -.
DR   PhylomeDB; Q89EA0; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015138; F:fumarate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015366; F:malate:proton symporter activity; IBA:GO_Central.
DR   GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0070778; P:L-aspartate transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..442
FT                   /note="C4-dicarboxylate transport protein 4"
FT                   /id="PRO_0000321972"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
SQ   SEQUENCE   442 AA;  46752 MW;  8060838119E22335 CRC64;
     MTQIAIQPAI RRRHQPWYKI LYVQVLIAIV LGVLIGYFYP DFGKELKPLG DGFIALIKMM
     IAPVIFCTVV HGISSMGDLK RVGRVGLKSL IYFESVSTVA LAVGLLVGEV LQPGHGFNID
     PATIDPKSVA TYVTKAKEEG IVAHLMAIIP DSYVGAIARG DLLQVLLISI LSGFAIAFLG
     KAGEPIADAI DKAAKMFFGI IRIIVRVAPV GAFGAMAFTV GAYGLGSLLN LAALIGTFYL
     TSILFVLIVL GAIARLAGFS ILRFIAYIKD ELLIVLGTSS SETVLPQMIQ KMEHLGASRS
     VVGLVIPTGY SFNLDGTNIY MTLATLFLAQ ATNTHLTIWQ ELGILGIAMI TSKGASGVTG
     AGFITLAATL SIVPDIPIQS IAILVGIDKF MSECRALTNL IGNGVACVVI SISEGELDRD
     ALHETMAHPL EIGEALEPGG GA