ID   DCTA_CAUVN              Reviewed;         417 AA.
AC   B8H0N0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2015, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=C4-dicarboxylate transport protein {ECO:0000255|HAMAP-Rule:MF_01300};
GN   Name=dctA {ECO:0000255|HAMAP-Rule:MF_01300}; OrderedLocusNames=CCNA_00664;
OS   Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=565050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=20472802; DOI=10.1128/jb.00255-10;
RA   Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA   Walunas T.L., Crosson S.;
RT   "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL   J. Bacteriol. 192:3678-3688(2010).
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01300}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01300}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01300}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000255|HAMAP-Rule:MF_01300}.
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DR   EMBL; CP001340; ACL94129.2; -; Genomic_DNA.
DR   RefSeq; WP_024265578.1; NC_011916.1.
DR   RefSeq; YP_002516037.2; NC_011916.1.
DR   AlphaFoldDB; B8H0N0; -.
DR   SMR; B8H0N0; -.
DR   EnsemblBacteria; ACL94129; ACL94129; CCNA_00664.
DR   GeneID; 7330471; -.
DR   KEGG; ccs:CCNA_00664; -.
DR   PATRIC; fig|565050.3.peg.655; -.
DR   HOGENOM; CLU_019375_7_0_5; -.
DR   OrthoDB; 781228at2; -.
DR   Proteomes; UP000001364; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..417
FT                   /note="C4-dicarboxylate transport protein"
FT                   /id="PRO_1000165284"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
SQ   SEQUENCE   417 AA;  43764 MW;  2CBE9C91D03D208B CRC64;
     MKSIYVQVLI AIVLGVLVGA IWPQIGVALK PLGDGFIKLI KLVIAPVIFC TVAGGIARMG
     DMKAFGRVGV KALIYFEVVS TLALVIGLVV GRLIQPGAGF NIDPATLDAS IAAGYVEKAQ
     HGEGMVAYLL HLIPDTFIGA FADGNLLQVL VIAILTGFAC VRMGDFGEKV AHVLDETSKL
     FFGIIHIVVR LAPIGAFGAM GFTIGKYGVE ALVQLGALVA TFYVTSLLFV LVVLGGIAWV
     SGFSIFRFLA YIREELLIVL GTSSSESVLP QMMEKLENAG ARRSVVGLVI PTGYSFNLDG
     TNIYMTLATL FLAQATNTPL SLGQELALLG VAMLTSKGAS GVTGAGFITL AATLAVVPDI
     PIAALAILVG VDRFMSECRA LTNLVGNGVA TLVVARWEGA LDRQRLDRVL RGAPATE