DCTA_ECO57
ID DCTA_ECO57 Reviewed; 428 AA.
AC Q8X5M2;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Aerobic C4-dicarboxylate transport protein;
GN Name=dctA {ECO:0000255|HAMAP-Rule:MF_01300};
GN OrderedLocusNames=Z4942, ECs4408;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Responsible for the aerobic transport of the dicarboxylates
CC fumarate and malate and to a lesser extent succinate, from the
CC periplasm across the inner membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01300}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01300}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000255|HAMAP-Rule:MF_01300}.
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DR EMBL; AE005174; AAG58669.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB37831.1; -; Genomic_DNA.
DR PIR; A86026; A86026.
DR PIR; H91179; H91179.
DR RefSeq; NP_312435.1; NC_002695.1.
DR RefSeq; WP_000858212.1; NZ_SEKU01000003.1.
DR AlphaFoldDB; Q8X5M2; -.
DR SMR; Q8X5M2; -.
DR STRING; 155864.EDL933_4781; -.
DR EnsemblBacteria; AAG58669; AAG58669; Z4942.
DR EnsemblBacteria; BAB37831; BAB37831; ECs_4408.
DR GeneID; 915733; -.
DR KEGG; ece:Z4942; -.
DR KEGG; ecs:ECs_4408; -.
DR PATRIC; fig|386585.9.peg.4607; -.
DR eggNOG; COG1301; Bacteria.
DR HOGENOM; CLU_019375_7_0_6; -.
DR OMA; YLYIAVI; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3860.10; -; 1.
DR HAMAP; MF_01300; C4_dicarb_transport; 1.
DR InterPro; IPR023954; C4_dicarb_transport.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865; PTHR42865; 1.
DR Pfam; PF00375; SDF; 1.
DR SUPFAM; SSF118215; SSF118215; 1.
DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..428
FT /note="Aerobic C4-dicarboxylate transport protein"
FT /id="PRO_0000202095"
FT TRANSMEM 5..27
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 47..64
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 77..99
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 141..163
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 184..206
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 326..348
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 352..374
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
SQ SEQUENCE 428 AA; 45408 MW; 0EE32F987B62D226 CRC64;
MKTSLFKSLY FQVLTAIAIG ILLGHFYPEI GEQMKPLGDG FVKLIKMIIA PVIFCTVVTG
IAGMESMKAV GRTGAVALLY FEIVSTIALI IGLIIVNVVQ PGAGMNVDPA TLDAKAVAVY
ADQAKDQGIV AFIMDVIPAS VIGAFASGNI LQVLLFAVLF GFALHRLGSK GQLIFNVIES
FSQVIFGIIN MIMRLAPIGA FGAMAFTIGK YGVGTLVQLG QLIICFYITC ILFVVLVLGS
IAKATGFSIF KFIRYIREEL LIVLGTSSSE SALPRMLDKM EKLGCRKSVV GLVIPTGYSF
NLDGTSIYLT MAAVFIAQAT NSQMDIVHQI TLLIVLLLSS KGAAGVTGSG FIVLAATLSA
VGHLPVAGLA LILGIDRFMS EARALTNLVG NGVATIVVAK WVKELDHKKL DDALNNRAPD
GKTHELSS
