ID   DCTA_NEOGA              Reviewed;         461 AA.
AC   Q9X7K6;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=C4-dicarboxylate transport protein;
GN   Name=dctA;
OS   Neorhizobium galegae (Rhizobium galegae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Neorhizobium.
OX   NCBI_TaxID=399;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HAMBI 1174;
RX   PubMed=10474187; DOI=10.1111/j.1574-6968.1999.tb13735.x;
RA   Suominen L., Paulin L., Saano A., Saren A.-M., Tas E., Lindstroem K.;
RT   "Identification of nodulation promoter (nod-box) regions of Rhizobium
RT   galegae.";
RL   FEMS Microbiol. Lett. 177:217-223(1999).
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the inner
CC       membrane. This transport system plays an important role in the energy
CC       supply of rhizobium-legume symbionts (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR   EMBL; AJ132912; CAB40566.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9X7K6; -.
DR   SMR; Q9X7K6; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..461
FT                   /note="C4-dicarboxylate transport protein"
FT                   /id="PRO_0000202105"
FT   TRANSMEM        20..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   461 AA;  48599 MW;  6EB7FA6AD63F3E69 CRC64;
     MIANQAAETP RKVPFYRHLY VQVLTAIVAG IMVGNFYPDL GASLKPLGDA FIKLVSMIIA
     PVIFLTVTTG IAGMADLKKV GRVAGKAILY FTVFSTLALA VGLLVANILR PGAGMHINPA
     TLDPKAVAAY ATNAHGTTAV SFLMKIIPNT IVGAFADGNI LQVLFISILF GISIAMVGDR
     GQPVVRFLDA LTEPMFKLTA VLMKAAPIGA FGAMAFTNGK YGIASLINLV MLIGTFYLTS
     LLFVLVVLGA VARCNGFSVI ALIAYIKEEI LLVLGTSSSE AALPGLMAKM EQVGCKRSVV
     GLVVPTGYSF NLDGTNIYMT LASLFIAQAT DTPLTLADQI LLLLVAMLSS KGSAGITGAG
     FITLAATLSA VPSVPVAGMA LILGIDRFMS ESRAITNLIG NAIATLVVAN WEGDLDRGRM
     TVRWPGNQRW TKFNNKMFKL ERGFRAPTVD VDCFGAGPAQ P