DCTA_PECAS
ID DCTA_PECAS Reviewed; 430 AA.
AC Q6CYZ1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=C4-dicarboxylate transport protein {ECO:0000255|HAMAP-Rule:MF_01300};
GN Name=dctA {ECO:0000255|HAMAP-Rule:MF_01300}; OrderedLocusNames=ECA4362;
OS Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS carotovora subsp. atroseptica).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Pectobacterium.
OX NCBI_TaxID=218491;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCRI 1043 / ATCC BAA-672;
RX PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT subsp. atroseptica and characterization of virulence factors.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC succinate, fumarate, and malate from the periplasm across the membrane.
CC {ECO:0000255|HAMAP-Rule:MF_01300}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01300}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01300}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000255|HAMAP-Rule:MF_01300}.
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DR EMBL; BX950851; CAG77259.1; -; Genomic_DNA.
DR RefSeq; WP_011095825.1; NC_004547.2.
DR AlphaFoldDB; Q6CYZ1; -.
DR SMR; Q6CYZ1; -.
DR STRING; 218491.ECA4362; -.
DR EnsemblBacteria; CAG77259; CAG77259; ECA4362.
DR GeneID; 57211055; -.
DR KEGG; eca:ECA4362; -.
DR PATRIC; fig|218491.5.peg.4445; -.
DR eggNOG; COG1301; Bacteria.
DR HOGENOM; CLU_019375_7_0_6; -.
DR OMA; YLYIAVI; -.
DR OrthoDB; 781228at2; -.
DR Proteomes; UP000007966; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3860.10; -; 1.
DR HAMAP; MF_01300; C4_dicarb_transport; 1.
DR InterPro; IPR023954; C4_dicarb_transport.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865; PTHR42865; 1.
DR Pfam; PF00375; SDF; 1.
DR SUPFAM; SSF118215; SSF118215; 1.
DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..430
FT /note="C4-dicarboxylate transport protein"
FT /id="PRO_1000067450"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01300"
SQ SEQUENCE 430 AA; 45607 MW; 15784CBDEABFEC48 CRC64;
MKTSIFKSLY FQVLAAITIG ILLGHFYPQL GEQMKPLGDG FVKLIKMIIA PVIFCTVVTG
IAGMESMKSV GRTGAAALLY FEVVSTIALI IGLVVVNVVQ PGVGMNIDPS TLDASAVAVY
TQQASQQGLI PFLMDVIPAS VVGAFASGNI LQVLLFAVMF GFALHRLGPK GKVIFDVIES
FSKVIFGVIN MIMKLAPLGA FGAMAFTIGK YGVGTLVQLG QLILCFYLTC ILFVFLVLGS
IAKATGFSIF KFIRYIREEL LIVLGTSSSE SVLPRMLEKM EKVGCKKSVV GLVIPTGYSF
NLDGTSIYLT MAAVFIAQAT NSHMDIWHQI TLLVVLLLSS KGAAGVTGSG FIVLAATLSA
VGHLPVAGLA LILGIDRFMS EARALTNLIG NGVATIVVAK YCRELDEKKL DAELSGNNKN
DNAATPTAQS