DCTA_RHILE
ID DCTA_RHILE Reviewed; 444 AA.
AC Q01857;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=C4-dicarboxylate transport protein;
GN Name=dctA;
OS Rhizobium leguminosarum.
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX NCBI_TaxID=384;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Ronson C.W.;
RL Submitted (DEC-1991) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC succinate, fumarate, and malate from the periplasm across the inner
CC membrane. This transport system plays an important role in the energy
CC supply of rhizobium-legume symbionts (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR EMBL; Z11529; CAA77618.1; -; Genomic_DNA.
DR PIR; S27384; S27384.
DR RefSeq; WP_018242998.1; NZ_WXXP01000006.1.
DR AlphaFoldDB; Q01857; -.
DR SMR; Q01857; -.
DR STRING; 936136.ARRT01000006_gene4358; -.
DR TCDB; 2.A.23.1.3; the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.
DR eggNOG; COG1301; Bacteria.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3860.10; -; 1.
DR HAMAP; MF_01300; C4_dicarb_transport; 1.
DR InterPro; IPR023954; C4_dicarb_transport.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865; PTHR42865; 1.
DR Pfam; PF00375; SDF; 1.
DR SUPFAM; SSF118215; SSF118215; 1.
DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..444
FT /note="C4-dicarboxylate transport protein"
FT /id="PRO_0000202106"
FT TRANSMEM 18..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..386
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 444 AA; 46045 MW; AA2A5EA9E6780653 CRC64;
MIAAPLDAVA GSKGKKPFYS HLYVQVLVAI AAGILLGHFY PELGTQLKPL GDAFIKLVKM
IIAPVIFLTV ATGIAGMSDL QKVGRVAGKA MLYFLTFSTL ALIIGLIVAN VVQPGAGMNI
DPASLDPAAV ATFAAKAHEQ SIVGFLTNII PTTIVGAFAD GDILQVLFFS VLFGIALAMV
GEKGEQVVNF LNSLTAPVFK LVAILMKAAP IGAFGAMAFT IGKYGVGSIA NLAMLIGTFY
ITSLLFVFIV LGAVARYNGF SIVALLRYIK EELLLVLGTS SSEAALPGLM NKMEKAGCKR
SVVGLVIPTG YSFNLDGTNI YMTLAALFIA QATGIHLSWG DQILLLLVAM LSSKGAAGIT
GAGFITLAAT LSVVPSVPVA GMALILGIDR FMSECRALTN LVGNAVATIV VARWENELDT
VQLAAALGGQ TGEDTSAAGL QPAE
