ID   ACT_CRYNH               Reviewed;         375 AA.
AC   P48465; J9VLP4;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2013, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Actin;
GN   ORFNames=CNAG_00483;
OS   Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS   CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=235443;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487;
RX   PubMed=8531025; DOI=10.1080/02681219580000521;
RA   Cox G.M., Rude T., Perfect J.R.;
RT   "The actin gene from Cryptococcus neoformans: structure and phylogenetic
RT   analysis.";
RL   J. Med. Vet. Mycol. 33:261-266(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487;
RX   PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA   Janbon G., Ormerod K.L., Paulet D., Byrnes E.J. III, Yadav V.,
RA   Chatterjee G., Mullapudi N., Hon C.-C., Billmyre R.B., Brunel F.,
RA   Bahn Y.-S., Chen W., Chen Y., Chow E.W.L., Coppee J.-Y., Floyd-Averette A.,
RA   Gaillardin C., Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S.,
RA   Hamlin J.L., Hsueh Y.-P., Ianiri G., Jones S., Kodira C.D., Kozubowski L.,
RA   Lam W., Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K.,
RA   Proux C., Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A.,
RA   Zeng Q., Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA   Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA   Cuomo C.A., Dietrich F.S.;
RT   "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT   grubii reveals complex RNA expression and microevolution leading to
RT   virulence attenuation.";
RL   PLoS Genet. 10:E1004261-E1004261(2014).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AFR92615.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U10867; AAC49074.1; -; Genomic_DNA.
DR   EMBL; CP003820; AFR92615.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_012046325.1; XM_012190935.1.
DR   AlphaFoldDB; P48465; -.
DR   SMR; P48465; -.
DR   SwissPalm; P48465; -.
DR   PRIDE; P48465; -.
DR   EnsemblFungi; AAW41026; AAW41026; CNA04650.
DR   EnsemblFungi; AFR92615; AFR92615; CNAG_00483.
DR   GeneID; 23884285; -.
DR   HOGENOM; CLU_027965_0_2_1; -.
DR   Proteomes; UP000010091; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   CHAIN           1..375
FT                   /note="Actin"
FT                   /id="PRO_0000088917"
FT   CONFLICT        100..101
FT                   /note="EH -> DD (in Ref. 1; AAC49074)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        126
FT                   /note="T -> S (in Ref. 1; AAC49074)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        223
FT                   /note="F -> C (in Ref. 1; AAC49074)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   375 AA;  41831 MW;  425CE4EFE6FC11A6 CRC64;
     MEEEVAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS
     KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKQNREKMT
     QIMFETFNAP AFYVSIQAVL SLYASGRTTG IVLDSGDGVT HTVPIYEGFS LPHAILRIDL
     AGRDLTDYLV KILMERGYLF TTSAEREIVR DIKEKLCYVA LDFEQELQTA AQSSQLEKSY
     ELPDGQVITI GNERFRCPEA LFQPSLLGLE AAGIHETTYN SIMKCDLDIR KDLYGNIVMS
     GGTTMYNGIA DRMQKEITAL APSSMKVKIV SPPERKYSVW IGGSILASLS TFQQMWIAKS
     EYDESGPSIV HRKCF