ID   DCTA_SALTY              Reviewed;         428 AA.
AC   P50334;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Aerobic C4-dicarboxylate transport protein;
GN   Name=dctA; OrderedLocusNames=STM3614;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=8955389; DOI=10.1128/jb.178.24.7099-7105.1996;
RA   Baker K.E., Ditullio K.P., Neuhard J., Kelln R.A.;
RT   "Utilization of orotate as a pyrimidine source by Salmonella typhimurium
RT   and Escherichia coli requires the dicarboxylate transport protein encoded
RT   by dctA.";
RL   J. Bacteriol. 178:7099-7105(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the inner
CC       membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR   EMBL; X91397; CAA62742.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL22474.1; -; Genomic_DNA.
DR   RefSeq; NP_462515.1; NC_003197.2.
DR   RefSeq; WP_000858228.1; NC_003197.2.
DR   AlphaFoldDB; P50334; -.
DR   SMR; P50334; -.
DR   STRING; 99287.STM3614; -.
DR   PaxDb; P50334; -.
DR   EnsemblBacteria; AAL22474; AAL22474; STM3614.
DR   GeneID; 1255137; -.
DR   KEGG; stm:STM3614; -.
DR   PATRIC; fig|99287.12.peg.3820; -.
DR   HOGENOM; CLU_019375_7_0_6; -.
DR   OMA; YLYIAVI; -.
DR   PhylomeDB; P50334; -.
DR   BioCyc; SENT99287:STM3614-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015138; F:fumarate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015366; F:malate:proton symporter activity; IBA:GO_Central.
DR   GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0070778; P:L-aspartate transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR42865; PTHR42865; 1.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..428
FT                   /note="Aerobic C4-dicarboxylate transport protein"
FT                   /id="PRO_0000202112"
FT   TRANSMEM        5..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   428 AA;  45449 MW;  86CE44C25539B48C CRC64;
     MKTSLFKSLY FQVLTAIAIG ILLGHYYPEL GAQMKPLGDA FVKLIKMIIA PVIFCTVVTG
     IAGMESMKAV GRTGAVALLY FEIVSTIALI IGLIIVNVVQ PGAGMNVDPA TLDAQAVAVY
     AAQAKEQGII AFLMDVIPGS VIGAFASGNI LQVLLFAVLF GFALHRLGSK GQLIFNVIES
     FSQVIFGIIN MIMRLAPIGA FGAMAFTIGK YGVGSLVQLG QLIICFYITC ILFVVVVLGT
     IARVTGFSIF KFIRYIREEL LIVLGTSSSE SALPRMLDKM EKLGCRKSVV GLVIPTGYSF
     NLDGTSIYLT MAAVFIAQAT NSHMDIFHQI TLLVVLLLSS KGAAGVTGSG FIVLAATISA
     VGHLPVAGLA LILGIDRFMS EARALTNLVG NGVATVVVAK WVKELDHQKL DDVLNNRAPD
     GKTHEISS