ID   ACT_CYAM1               Reviewed;         377 AA.
AC   P53500; A0A125YHS2; M1VDX9; Q54A44;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Actin;
GN   ORFNames=CYME_CMM237C;
OS   Cyanidioschyzon merolae (strain NIES-3377 / 10D) (Unicellular red alga).
OC   Eukaryota; Rhodophyta; Bangiophyceae; Cyanidiales; Cyanidiaceae;
OC   Cyanidioschyzon.
OX   NCBI_TaxID=280699;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8575024; DOI=10.1007/bf00310820;
RA   Takahashi H., Takano H., Yokoyama A., Hara Y., Kawano S., Toh-e A.,
RA   Kuroiwa T.;
RT   "Isolation, characterization and chromosomal mapping of an actin gene from
RT   the primitive red alga Cyanidioschyzon merolae.";
RL   Curr. Genet. 28:484-490(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NIES-3377 / 10D;
RX   PubMed=12664168; DOI=10.1007/s00239-002-2419-9;
RA   Nozaki H., Matsuzaki M., Takahara M., Misumi O., Kuroiwa H., Hasegawa M.,
RA   Shin-i T., Kohara Y., Ogasawara N., Kuroiwa T.;
RT   "The phylogenetic position of red algae revealed by multiple nuclear genes
RT   from mitochondria-containing eukaryotes and an alternative hypothesis on
RT   the origin of plastids.";
RL   J. Mol. Evol. 56:485-497(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-3377 / 10D;
RX   PubMed=15071595; DOI=10.1038/nature02398;
RA   Matsuzaki M., Misumi O., Shin-i T., Maruyama S., Takahara M.,
RA   Miyagishima S., Mori T., Nishida K., Yagisawa F., Nishida K., Yoshida Y.,
RA   Nishimura Y., Nakao S., Kobayashi T., Momoyama Y., Higashiyama T.,
RA   Minoda A., Sano M., Nomoto H., Oishi K., Hayashi H., Ohta F., Nishizaka S.,
RA   Haga S., Miura S., Morishita T., Kabeya Y., Terasawa K., Suzuki Y.,
RA   Ishii Y., Asakawa S., Takano H., Ohta N., Kuroiwa H., Tanaka K.,
RA   Shimizu N., Sugano S., Sato N., Nozaki H., Ogasawara N., Kohara Y.,
RA   Kuroiwa T.;
RT   "Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon
RT   merolae 10D.";
RL   Nature 428:653-657(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-3377 / 10D;
RX   PubMed=17623057; DOI=10.1186/1741-7007-5-28;
RA   Nozaki H., Takano H., Misumi O., Terasawa K., Matsuzaki M., Maruyama S.,
RA   Nishida K., Yagisawa F., Yoshida Y., Fujiwara T., Takio S., Tamura K.,
RA   Chung S.J., Nakamura S., Kuroiwa H., Tanaka K., Sato N., Kuroiwa T.;
RT   "A 100%-complete sequence reveals unusually simple genomic features in the
RT   hot-spring red alga Cyanidioschyzon merolae.";
RL   BMC Biol. 5:28-28(2007).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- FUNCTION: Essential component of cell cytoskeleton; plays an important
CC       role in cytoplasmic streaming, cell shape determination, cell division,
CC       organelle movement and extension growth.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; D32140; BAA06866.1; -; Genomic_DNA.
DR   EMBL; AB095179; BAC67664.1; -; Genomic_DNA.
DR   EMBL; AP006495; BAM81077.1; -; Genomic_DNA.
DR   PIR; S65079; S65079.
DR   RefSeq; XP_005537113.1; XM_005537056.1.
DR   AlphaFoldDB; P53500; -.
DR   SMR; P53500; -.
DR   STRING; 45157.CMM237CT; -.
DR   PRIDE; P53500; -.
DR   EnsemblPlants; CMM237CT; CMM237CT; CMM237C.
DR   GeneID; 16994952; -.
DR   Gramene; CMM237CT; CMM237CT; CMM237C.
DR   KEGG; cme:CYME_CMM237C; -.
DR   eggNOG; KOG0676; Eukaryota.
DR   OrthoDB; 649708at2759; -.
DR   Proteomes; UP000007014; Chromosome 13.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..377
FT                   /note="Actin"
FT                   /id="PRO_0000088919"
SQ   SEQUENCE   377 AA;  42005 MW;  8177530ADAF8E5C5 CRC64;
     MTEEEITALV IDNGSGMVKA GFAGDDAPRA VFPSIVGRPR HQAVMVGMGQ KDSYVGDEAQ
     SKRGILSLKY PIEHGIVTNW DDMEKIWYHT FYNELRISPE DHPVLLTEAP LNPKANREKM
     TQIMFETFNV PAMYVAIQAV LSLYASGRTT GIVVDSGDGV THTVPIYEGY ALPHAIMRID
     LAGRDLTDYL AKILTERGYS FTTTAEREIV RDIKEKCCYV AQDYDHELEI ASSQPAKIDK
     QYELPDGQII TIGSERFRCP EVLFQPSLIG MEGEGIHNVA YQSIMKCDVD IRKDLYANVV
     LSGGTTMFPG IADRMQRELA SVAPSSVKIK LVAPAERKYS VWIGGSILAS LSTFQQMWIS
     KAEYDEFGPS VVHRKCF